Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells. - Wikidata - wikimedia - TriplyDB

Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells.

Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells.

http://www.wikidata.org/entity/Q36429424

about

Megakaryocyte- and megakaryocyte precursor-related gene therapies Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy.CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes Glanzmann thrombasthenia: state of the art and future directions.Factor IX ectopically expressed in platelets can be stored in alpha-granules and corrects the phenotype of hemophilia B mice.Platelets as delivery systems for disease treatments Platelet gene therapy improves hemostatic function for integrin alphaIIbbeta3-deficient dogs.Platelet specific promoters are insufficient to express protease activated receptor 1 (PAR1) transgene in mouse platelets.Gene therapy for platelet disorders: studies with Glanzmann's thrombasthenia.Methods for genetic modification of megakaryocytes and platelets.Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A.High efficiency gene transfer to airways of mice using influenza hemagglutinin pseudotyped lentiviral vectors.Physiological and tissue-specific vectors for treatment of inherited diseases.Genetic engineering of platelets to neutralize circulating tumor cells Biosynthesis of FVIII in megakaryocytic cells: improved production and biochemical characterization.Targeting platelet GPIbalpha transgene expression to human megakaryocytes and forming a complete complex with endogenous GPIbbeta and GPIX.Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies.Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia.Induction of megakaryocytes to synthesize and store a releasable pool of human factor VIII.Identification of a gene element essential for leukemia-specific expression of transgenes.Ultrafine carbon particles induce interleukin-8 gene transcription and p38 MAPK activation in normal human bronchial epithelial cells.

P2860

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P2860

Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells.

http://www.wikidata.org/entity/Q36429424

description

1999 nî lūn-bûn

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1999年の論文

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年學術文章

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1999年學術文章

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1999年學術文章

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name

Integrin alphaIIb promoter-tar ...... ced human hematopoietic cells.

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Integrin alphaIIb promoter-tar ...... ced human hematopoietic cells.

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Integrin alphaIIb promoter-tar ...... ced human hematopoietic cells.

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PNAS.96.17.9654

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Integrin alphaIIb promoter-tar ...... ced human hematopoietic cells.

@en

P2093

D A Wilcox

http://www.w3.org/2001/XMLSchema#string

G C White

http://www.w3.org/2001/XMLSchema#string

J C Olsen

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L Ishizawa

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M Griffith

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P2860

Megakaryocytic and erythrocytic lineages share specific transcription factors

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter.

A 2.7-kb portion of the 5' flanking region of the murine glycoprotein alphaIIb gene is transcriptionally active in primitive hematopoietic progenitor cells.

Effect of host modification and age on airway epithelial gene transfer mediated by a murine leukemia virus-derived vector

Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional.

A new family of murine retroviral vectors with extended multiple cloning sites for gene insertion.

Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex.

Efficient expression of protein coding genes from the murine U1 small nuclear RNA promoters.

Transcriptional regulation of alpha IIb integrin gene expression during megakaryocytic differentiation of K562 cells. Role of a silencer element.

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scholarly article

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10.1073/PNAS.96.17.9654

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22265

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