Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex.
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Glanzmann thrombastheniaStructure and function of the platelet integrin alphaIIbbeta3Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent proteinGreen fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand bindingNischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migrationThe GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain.Dominant inheritance of a novel integrin beta3 mutation associated with a hereditary macrothrombocytopenia and platelet dysfunction in two Italian families.Glanzmann thrombasthenia: state of the art and future directions.The leukocyte integrins.L718P mutation in the membrane-proximal cytoplasmic tail of beta 3 promotes abnormal alpha IIb beta 3 clustering and lipid microdomain coalescence, and associates with a thrombasthenia-like phenotypeDemystified...adhesion molecule deficiencies.Integrin αIIb-mediated PI3K/Akt activation in platelets.Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptorsReconstruction of integrin activation.The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation.Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3Integrin-dependent control of translation: engagement of integrin alphaIIbbeta3 regulates synthesis of proteins in activated human platelets.Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signalingIntegrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells.Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human plateletsAntithrombotic effects of targeting alphaIIbbeta3 signaling in platelets.Do cell junction protein mutations cause an airway phenotype in mice or humans?Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment.Talin and kindlin: the one-two punch in integrin activation.A mutation in the β3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of αIIb β3 to an active state.A 13-bp deletion in alpha(IIb) gene is a founder mutation that predominates in Palestinian-Arab patients with Glanzmann thrombasthenia.Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3.A Val193Met mutation in GPIIIa results in a GPIIb/IIIa receptor with a constitutively high affinity for a small ligand.A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1.The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling.A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation.The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases.Cooperative role of the membrane-proximal and -distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIb beta3 activation.Mutations in the beta3 gene giving rise to type I Glanzmann thrombasthenia in two families in Portugal.Mutations of the integrin αIIb/β3 intracytoplasmic salt bridge cause macrothrombocytopenia and enlarged platelet α-granules.Pathological shear stress directly regulates platelet alphaIIbbeta3 signaling.Distinct roles of ligand affinity and cytoskeletal anchorage in alphaIIbbeta3 (GP IIb/IIIa)-mediated cell aggregation and adhesion.Tyrosine phosphorylation of the integrin beta 3 subunit regulates beta 3 cleavage by calpain.
P2860
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P2860
Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Truncation of the cytoplasmic ...... ing through the integrin alpha
@nl
Truncation of the cytoplasmic ...... egrin alpha(IIb)beta3 complex.
@en
type
label
Truncation of the cytoplasmic ...... ing through the integrin alpha
@nl
Truncation of the cytoplasmic ...... egrin alpha(IIb)beta3 complex.
@en
prefLabel
Truncation of the cytoplasmic ...... ing through the integrin alpha
@nl
Truncation of the cytoplasmic ...... egrin alpha(IIb)beta3 complex.
@en
P2093
P2860
P356
P1476
Truncation of the cytoplasmic ...... egrin alpha(IIb)beta3 complex.
@en
P2093
P2860
P304
P356
10.1172/JCI119780
P407
P577
1997-11-01T00:00:00Z