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MHC class II proteins and disease: a structural perspective.

MHC class II proteins and disease: a structural perspective.

http://www.wikidata.org/entity/Q36430136

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Identification of a novel HLA-DPB1 allele (DPB1*1902) by haplotype-specific extraction and nucleotide sequencing Role of plasmacytoid dendritic cells for aberrant class II expression in exocrine glands from estrogen-deficient mice of healthy background Crystal structure of HLA-DP2 and implications for chronic beryllium disease The human Major Histocompatibility Complex as a paradigm in genomics research Interrogating the major histocompatibility complex with high-throughput genomics The genetics of complex cholestatic disorders Risk factors and primary prevention trials for type 1 diabetes Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis Antigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune Diseases Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes Predicting Hemagglutinin MHC-II Ligand Analogues in Anti-TNFα Biologics: Implications for Immunogenicity of Pharmaceutical Proteins High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis NNAlign: a platform to construct and evaluate artificial neural network models of receptor-ligand interactions.A time transect of exomes from a Native American population before and after European contact Genomic structure of the horse major histocompatibility complex class II region resolved using PacBio long-read sequencing technology.Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.Anchor side chains of short peptide fragments trigger ligand-exchange of class II MHC molecules A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene.Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cells Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model.An automated framework for understanding structural variations in the binding grooves of MHC class II molecules Limitations of Ab initio predictions of peptide binding to MHC class II molecules Insights into the ancestral organisation of the mammalian MHC class II region from the genome of the pteropid bat, Pteropus alecto.Peptide binding predictions for HLA DR, DP and DQ molecules Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift Peptide binding prediction for the human class II MHC allele HLA-DP2: a molecular docking approach.HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease HLA-DP2 binding prediction by molecular dynamics simulations.Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation The human cancer antigen mesothelin is more efficiently presented to the mouse immune system when targeted to the DEC-205/CD205 receptor on dendritic cells.Peanut-allergic subjects and their peanut-tolerant siblings have large differences in peanut-specific IgG that are independent of HLA class II.Regulation of major histocompatibility complex class II gene expression, genetic variation and disease.Survey of major histocompatibility complex class II diversity in pig-tailed macaques.HLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM.Immune pathways for translating viral infection into chronic airway disease.Prediction of peptides binding to MHC class I and II alleles by temporal motif mining

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MHC class II proteins and disease: a structural perspective.

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2006 nî lūn-bûn

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2006年学术文章

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MHC class II proteins and disease: a structural perspective.

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Nature Reviews Immunology

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MHC class II proteins and disease: a structural perspective.

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Christian Siebold

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Jack L Strominger

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P2860

Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans.

Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease

The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase

Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactiv

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice

Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif

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271-282

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10.1038/NRI1805

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