ITAM-mediated tonic signalling through pre-BCR and BCR complexes. - Wikidata - wikimedia - TriplyDB

ITAM-mediated tonic signalling through pre-BCR and BCR complexes.

ITAM-mediated tonic signalling through pre-BCR and BCR complexes.

http://www.wikidata.org/entity/Q36430140

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The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85 Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor Lipid rafts and B cell signaling Emerging therapeutic strategies for Epstein-Barr virus+ post-transplant lymphoproliferative disorder Bruton tyrosine kinase inhibitors: a promising novel targeted treatment for B cell lymphomas Bruton's tyrosine kinase inhibitors and their clinical potential in the treatment of B-cell malignancies: focus on ibrutinib Phosphoinositides: tiny lipids with giant impact on cell regulation Primary immunoglobulin repertoire development: time and space matter Targeting CD19 in B-cell lymphoma: emerging role of SAR3419 Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling Tyrosine phosphorylation within the intrinsically disordered cytosolic domains of the B-cell receptor: an NMR-based structural analysis Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis Association of reactive oxygen species-mediated signal transduction with in vitro apoptosis sensitivity in chronic lymphocytic leukemia B cells G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2 Micromanagement of lymphomas.Patterns of receptor revision in the immunoglobulin heavy chains of a teleost fish Augmented B lymphocyte response to antigen in the absence of antigen-induced B lymphocyte signaling in an IgG-transgenic mouse line Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation.EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway.Oncogenic activation of NF-kappaB.Getting Syk: spleen tyrosine kinase as a therapeutic target.Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival.The impact of CDK inhibition in human malignancies associated with pronounced defects in apoptosis: advantages of multi-targeting small molecules.Dipeptidyl peptidase 2 apoptosis assay determines the B-cell activation stage and predicts prognosis in chronic lymphocytic leukemia FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development.Multiple factors influence the contribution of individual immunoglobulin light chain genes to the naïve antibody repertoire Inhibition of human diffuse large B-cell lymphoma growth by JC polyomavirus-like particles delivering a suicide gene Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.Suppression of the LMP2A target gene, EGR-1, protects Hodgkin's lymphoma cells from entry to the EBV lytic cycle.Oligomerization and nanocluster organization render specificity.Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase.The development of mature B lymphocytes requires the combined function of CD19 and the p110δ subunit of PI3K A mouse variable gene fragment binds to DNA independently of the BCR context: a possible role for immature B-cell repertoire establishment.Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects

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P2860

ITAM-mediated tonic signalling through pre-BCR and BCR complexes.

http://www.wikidata.org/entity/Q36430140

description

2006 nî lūn-bûn

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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2006年學術文章

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2006年學術文章

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name

ITAM-mediated tonic signalling through pre-BCR and BCR complexes.

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ITAM-mediated tonic signalling through pre-BCR and BCR complexes.

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type

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ITAM-mediated tonic signalling through pre-BCR and BCR complexes.

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ITAM-mediated tonic signalling through pre-BCR and BCR complexes.

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prefLabel

ITAM-mediated tonic signalling through pre-BCR and BCR complexes.

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ITAM-mediated tonic signalling through pre-BCR and BCR complexes.

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Nature Reviews Immunology

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ITAM-mediated tonic signalling through pre-BCR and BCR complexes.

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John G Monroe

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P2860

T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression

Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering.

Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases

MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture

Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling

Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.

Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex

Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development

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283-294

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10.1038/NRI1808

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