An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro
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Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cellsFollicular helper T cells: lineage and locationMimotopes for alloreactive and conventional T cells in a peptide-MHC display libraryUse of soluble MHC class II/peptide multimers to detect antigen-specific T cells in human diseaseLower Affinity T Cells are Critical Components and Active Participants of the Immune ResponseNarrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell ResponseEffective T helper cell responses against retroviruses: are all clonotypes equal?The role of naive T cell precursor frequency and recruitment in dictating immune response magnitudeAlternate interactions define the binding of peptides to the MHC molecule IA(b).Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC MoleculesDynamics of CD8+ T cell priming by dendritic cells in intact lymph nodesBim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasisImmunization with pre-erythrocytic antigen CelTOS from Plasmodium falciparum elicits cross-species protection against heterologous challenge with Plasmodium bergheiImaging effector functions of human cytotoxic CD4+ T cells specific for Plasmodium falciparum circumsporozoite protein.Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses.CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signalsUse of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands.HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity.Low Antigen Dose in Adjuvant-Based Vaccination Selectively Induces CD4 T Cells with Enhanced Functional Avidity and Protective Efficacy.A detailed characterisation of the distribution and presentation of DNA vaccine encoded antigenAn affinity/avidity model of peripheral T cell regulationManipulating antigenic ligand strength to selectively target myelin-reactive CD4+ T cells in EAE.Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.Human immunodeficiency virus type 1 envelope epitope-specific CD4(+) T lymphocytes in simian/human immunodeficiency virus-infected and vaccinated rhesus monkeys detected using a peptide-major histocompatibility complex class II tetramerCutting Edge: Limiting amounts of IL-7 do not control contraction of CD4+ T cell responsesRobust antigen specific th17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection.Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy.Peptide-MHC class II complex stability governs CD4 T cell clonal selection.A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequenciesBim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory.Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputsTolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.Immune responses to coiled coil supramolecular biomaterials.IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization.Qualitative differences between naïve and memory T cells.Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover.T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.Duration of antigen availability influences the expansion and memory differentiation of T cells.Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells.Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.
P2860
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P2860
An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
An inverse relationship betwee ...... responses in vivo and in vitro
@ast
An inverse relationship betwee ...... responses in vivo and in vitro
@en
type
label
An inverse relationship betwee ...... responses in vivo and in vitro
@ast
An inverse relationship betwee ...... responses in vivo and in vitro
@en
prefLabel
An inverse relationship betwee ...... responses in vivo and in vitro
@ast
An inverse relationship betwee ...... responses in vivo and in vitro
@en
P2093
P2860
P356
P1476
An inverse relationship betwee ...... responses in vivo and in vitro
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.17.9781
P407
P577
1999-08-01T00:00:00Z