Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.
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Research Progress on Signaling Pathway-Associated Oxidative Stress in Endothelial Cells.Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathwaysRepurposing itraconazole as an anticancer agent.Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics.NPC-26 kills human colorectal cancer cells via activating AMPK signaling.Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis.α-Mangostin protects against high-glucose induced apoptosis of human umbilical vein endothelial cells.Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth.VDAC1 is a molecular target in glioblastoma, with its depletion leading to reprogrammed metabolism and reversed oncogenic properties.Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.Itraconazole attenuates hepatic gluconeogenesis and promotes glucose uptake by regulating AMPK pathway.AMPK is activated early in cerebellar granule cells undergoing apoptosis and influences VADC1 phosphorylation status and activity.Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling.MiR-490-3p Functions As a Tumor Suppressor by Inhibiting Oncogene VDAC1 Expression in Colorectal Cancer.Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma.VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis.
P2860
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P2860
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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name
Antifungal drug itraconazole t ...... ing axis in endothelial cells.
@ast
Antifungal drug itraconazole t ...... ing axis in endothelial cells.
@en
type
label
Antifungal drug itraconazole t ...... ing axis in endothelial cells.
@ast
Antifungal drug itraconazole t ...... ing axis in endothelial cells.
@en
prefLabel
Antifungal drug itraconazole t ...... ing axis in endothelial cells.
@ast
Antifungal drug itraconazole t ...... ing axis in endothelial cells.
@en
P2093
P2860
P50
P356
P1476
Antifungal drug itraconazole t ...... ing axis in endothelial cells.
@en
P2093
Kalyan Pasunooti
Kirill Gorshkov
Liang Zhao
Marco Colombini
Ruo-jing Li
Thomas Hartung
Wenzhi Tan
Yingming Zhao
P2860
P304
P356
10.1073/PNAS.1512867112
P407
P577
2015-12-10T00:00:00Z