about
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAPEffect of nitroxoline on angiogenesis and growth of human bladder cancerTargeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in CancerPyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in CellsPersonalized chemotherapy profiling using cancer cell lines from selectable miceChemical genetics for therapeutic target mining.Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3.A novel Ca2+/calmodulin antagonist HBC inhibits angiogenesis and down-regulates hypoxia-inducible factor.Identification and validation of calmodulin as a binding protein of an anti-proliferative small molecule 3,4-dihydroisoquinolinium salt.Recent advances in drug repositioning for the discovery of new anticancer drugsIdentification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir.Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.Purpurin inhibits adipocyte-derived leucine aminopeptidase and angiogenesis in a zebrafish model.Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 InhibitorsThe Small Molecule R-(-)-β-O-Methylsynephrine Binds to Nucleoporin 153 kDa and Inhibits Angiogenesis.Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonismFirst quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass.Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway.Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.Substituted oxines inhibit endothelial cell proliferation and angiogenesis.Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells.Existing drugs and their application in drug discovery targeting cancer stem cells.Development of a new Ca2+/calmodulin antagonist and its anti-proliferative activity against colorectal cancer cells.Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro.Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells.Tricyclic thiazoles are a new class of angiogenesis inhibitorsCryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro.Global and focused transcriptional profiling of small molecule aminopeptidase N inhibitor reveals its mechanism of angiogenesis inhibition.Development of anangiogenesis-focused cDNA chip and validation of its functionality.Potent inhibition of in vivo angiogenesis and tumor growth by a novel cyclooxygenase-2 inhibitor, enoic acanthoic acid.Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth.Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata.Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.Discovery of gliotoxin as a new small molecule targeting thioredoxin redox system.Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole.Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cellsCholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer.Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferationBRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Joong Sup Shim
@ast
Joong Sup Shim
@en
Joong Sup Shim
@es
Joong Sup Shim
@nl
Joong Sup Shim
@sl
type
label
Joong Sup Shim
@ast
Joong Sup Shim
@en
Joong Sup Shim
@es
Joong Sup Shim
@nl
Joong Sup Shim
@sl
prefLabel
Joong Sup Shim
@ast
Joong Sup Shim
@en
Joong Sup Shim
@es
Joong Sup Shim
@nl
Joong Sup Shim
@sl
P108
P106
P1153
7201856110
P31
P496
0000-0003-0167-7307