Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.
about
Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotidesPrediction of amino acid positions specific for functional groups in a protein family based on local sequence similarity.Aryl Hydrocarbon Receptor-interacting Protein-like 1 Is an Obligate Chaperone of Phosphodiesterase 6 and Is Assisted by the γ-Subunit of Its Client.Identification of PDE5A:E90K: a polymorphism in the canine phosphodiesterase 5A gene affecting basal cGMP concentrations of healthy dogs.Mechanisms of mutant PDE6 proteins underlying retinal diseases.Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development.
P2860
Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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name
Identification of amino acid r ...... phodiesterases, PDE5 and PDE6.
@ast
Identification of amino acid r ...... phodiesterases, PDE5 and PDE6.
@en
type
label
Identification of amino acid r ...... phodiesterases, PDE5 and PDE6.
@ast
Identification of amino acid r ...... phodiesterases, PDE5 and PDE6.
@en
prefLabel
Identification of amino acid r ...... phodiesterases, PDE5 and PDE6.
@ast
Identification of amino acid r ...... phodiesterases, PDE5 and PDE6.
@en
P2093
P2860
P356
P1476
Identification of amino acid r ...... phodiesterases, PDE5 and PDE6.
@en
P2093
Jonathan H Quade
Karen L Carleton
Karyn B Cahill
Rick H Cote
P2860
P304
41406-41416
P356
10.1074/JBC.M112.389189
P407
P577
2012-10-02T00:00:00Z