An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies
about
Combining 2D and 3D in silico methods for rapid selection of potential PDE5 inhibitors from multimillion compounds' repositories: biological evaluation.Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.Utilization of protein intrinsic disorder knowledge in structural proteomics.Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development.
P2860
An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
An insight into the pharmacoph ...... and crystal structural studies
@ast
An insight into the pharmacoph ...... and crystal structural studies
@en
An insight into the pharmacoph ...... and crystal structural studies
@nl
type
label
An insight into the pharmacoph ...... and crystal structural studies
@ast
An insight into the pharmacoph ...... and crystal structural studies
@en
An insight into the pharmacoph ...... and crystal structural studies
@nl
prefLabel
An insight into the pharmacoph ...... and crystal structural studies
@ast
An insight into the pharmacoph ...... and crystal structural studies
@en
An insight into the pharmacoph ...... and crystal structural studies
@nl
P2093
P2860
P1476
An insight into the pharmacoph ...... and crystal structural studies
@en
P2093
Howard Robinson
Huanchen Wang
Yiqian Wan
P2860
P304
P356
10.1016/J.BCP.2008.01.019
P407
P50
P577
2008-05-01T00:00:00Z