Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome.
about
KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current.Regulation of the Kv2.1 potassium channel by MinK and MiRP1Intracellular domains interactions and gated motions of I(KS) potassium channel subunitsA carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.Interaction of KCNE subunits with the KCNQ1 K+ channel poreDynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2The KCNQ1 channel - remarkable flexibility in gating allows for functional versatilityDriving with no brakes: molecular pathophysiology of Kv7 potassium channelsKCNQ1 channel modulation by KCNE proteins via the voltage-sensing domainIndividual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits.KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channelKCNE2 and the K (+) channel: the tail wagging the dogIKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunitsKCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gateTwo open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channelsEvidence for KCNQ1 K+ channel expression in rat zymogen granule membranes and involvement in cholecystokinin-induced pancreatic acinar secretionConformational changes of an ion-channel during gating and emerging electrophysiologic properties: Application of a computational approach to cardiac Kv7.1.Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1.Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodiumDiscovery of a novel activator of KCNQ1-KCNE1 K channel complexes.Functional interactions between KCNE1 C-terminus and the KCNQ1 channel.KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two stepsN-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes.The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.MinK endows the I(Ks) potassium channel pore with sensitivity to internal tetraethylammoniumPore- and state-dependent cadmium block of I(Ks) channels formed with MinK-55C and wild-type KCNQ1 subunitsVoltage-gated proton channels.The KCNQ1 potassium channel: from gene to physiological function.Monogenic atrial fibrillation as pathophysiological paradigms.Genetic disorders of neuromuscular ion channels.Probing binding sites and mechanisms of action of an I(Ks) activator by computations and experiments.LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms.KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity.The fast and slow ups and downs of HCN channel regulation.Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channelPartial restoration of the long QT syndrome associated KCNQ1 A341V mutant by the KCNE1 β-subunitA multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis.Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be FunctionalTryptophan Scanning Mutagenesis Identifies the Molecular Determinants of Distinct Barttin Functions.Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits.
P2860
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P2860
Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Single-channel characteristics ...... s that cause long QT syndrome.
@ast
Single-channel characteristics ...... s that cause long QT syndrome.
@en
type
label
Single-channel characteristics ...... s that cause long QT syndrome.
@ast
Single-channel characteristics ...... s that cause long QT syndrome.
@en
prefLabel
Single-channel characteristics ...... s that cause long QT syndrome.
@ast
Single-channel characteristics ...... s that cause long QT syndrome.
@en
P2860
P356
P1476
Single-channel characteristics ...... s that cause long QT syndrome.
@en
P2093
S A Goldstein
P2860
P304
P356
10.1085/JGP.112.6.651
P577
1998-12-01T00:00:00Z