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Biological activities of toxins A and B of Clostridium difficile

Biological activities of toxins A and B of Clostridium difficile

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Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers The low molecular mass GTP-binding protein Rho is affected by toxin A from Clostridium difficile Purification and characterization of toxins A and B of Clostridium difficile Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit Clostridium difficile: its disease and toxins Effects of Clostridium difficile toxins A and B in rabbit small and large intestine in vivo and on cultured cells in vitro.Enzyme-linked immunosorbent assay for Clostridium difficile toxin A Human antibody response to Clostridium difficile toxin A in relation to clinical course of infection The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1beta, tumor necrosis factor alpha, and leukotrienes.Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium Toxin gene analysis of a variant strain of Clostridium difficile that causes human clinical disease.Purification and characterization of alpha-toxin produced by Clostridium novyi type A Survey of incidence of Clostridium difficile infection in Canadian hospitals and diagnostic approaches.Immunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A.Clostridium difficile recombinant toxin A repeating units as a carrier protein for conjugate vaccines: studies of pneumococcal type 14, Escherichia coli K1, and Shigella flexneri type 2a polysaccharides in mice.Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro Enterotoxigenicity of mature 45-kilodalton and processed 35-kilodalton forms of hemagglutinin protease purified from a cholera toxin gene-negative Vibrio cholerae non-O1, non-O139 strain.The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection.Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review.Asymptomatic neonatal colonisation by Clostridium difficile.Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotoxicity of C. difficile toxins.Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract.Clostridial enteric diseases of domestic animals.Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytes Clostridium difficile toxin B intoxicated mouse colonic epithelial CT26 cells stimulate the activation of dendritic cells.Intravenous immunoglobulin therapy for severe Clostridium difficile colitis Time-resolved amino acid uptake of Clostridium difficile 630Δerm and concomitant fermentation product and toxin formation.Toward a structural understanding of Clostridium difficile toxins A and B.Pseudomembranous colitis in Clostridium difficile-monoassociated rats.Effects of the two toxins of Clostridium difficile in antibiotic-associated cecitis in hamsters.Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.Immunogenicity and protective efficacy of Clostridium difficile spore proteins.Clostridium difficile: clinical disease and diagnosis Modulation of cytotoxin production by Clostridium difficile in the intestinal tracts of gnotobiotic mice inoculated with various human intestinal bacteria.Purification and characterization of an enterotoxin from Bacteroides fragilis.Localization of two epitopes recognized by monoclonal antibody PCG-4 on Clostridium difficile toxin A.

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P2860

Biological activities of toxins A and B of Clostridium difficile

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D E Lockwood

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D M Lyerly

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Purification and characterization of toxins A and B of Clostridium difficile

Pathophysiological effects of Vibrio cholerae and enterotoxigenic Escherichia coli and their exotoxins on eucaryotic cells

Clostridium difficile and the aetiology of pseudomembranous colitis.

Intestinal fluid accumulation induced by oral challenge with Vibrio cholerae or cholera toxin in infant mice

Morphology of experimental antibiotic-associated enterocolitis in the hamster: a model for human pseudomembranous colitis and antibiotic-associated diarrhoea.

Production of vascular permeability factor by enterotoxigenic Escherichia coli isolated from man.

Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia.

Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis.

Antibiotic-induced lethal enterocolitis in hamsters: studies with eleven agents and evidence to support the pathogenic role of toxin-producing Clostridia.

Partial purification of a toxin found in hamsters with antibiotic-associated colitis. Reversible binding of the toxin by cholestyramine.

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