Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro
about
Clostridium difficile toxins: mechanism of action and role in disease.Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosaToxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cellsClostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal EffectsThe Role of Rho GTPases in Toxicity of Clostridium difficile ToxinsUltrasensitive Detection and Quantification of Toxins for Optimized Diagnosis of Clostridium difficile InfectionClostridium difficile: epidemiology, diagnostic and therapeutic possibilities-a systematic reviewClostridial toxins: sensing a target in a hostile gut environment.Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanismStructural Determinants of Clostridium difficile Toxin A Glucosyltransferase ActivityInvolvement of nerves and calcium channels in the intestinal response to Clostridium difficile toxin A: an experimental study in rats in vivoNitric oxide donating compounds stimulate human colonic ion transport in vitro.Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammationTrends in Clostridium difficile Disease: Epidemiology and InterventionGlutamine and alanyl-glutamine increase RhoA expression and reduce Clostridium difficile toxin-a-induced intestinal epithelial cell damageSystems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control.Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.Clostridium difficile toxins A and B are cation-dependent UDP-glucose hydrolases with differing catalytic activities.Characterization of a cell surface protein of Clostridium difficile with adhesive propertiesMonocytes are highly sensitive to clostridium difficile toxin A-induced apoptotic and nonapoptotic cell deathNeurotensin is a proinflammatory neuropeptide in colonic inflammationImmunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A.Lactobacillus rhamnosus L34 and Lactobacillus casei L39 suppress Clostridium difficile-induced IL-8 production by colonic epithelial cellsRho GTPases dictate the mobility of the Na/H exchanger NHE3 in epithelia: role in apical retention and targeting.The concept of cellular "fight-or-flight" reaction to stress.GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitisSerum antitoxin antibodies mediate systemic and mucosal protection from Clostridium difficile disease in hamsters.Safety and immunogenicity of increasing doses of a Clostridium difficile toxoid vaccine administered to healthy adults.Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins.The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives.Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins.Clostridium difficile infection and inflammatory bowel disease: understanding the evolving relationship.Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation.p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis.Theodore E. Woodward Award. How bacterial enterotoxins work: insights from in vivo studies.Using phenotype microarrays to determine culture conditions that induce or repress toxin production by Clostridium difficile and other microorganisms.Clostridium difficile vaccine and serum immunoglobulin G antibody response to toxin APrimary human colonic myofibroblasts are resistant to Clostridium difficile toxin A-induced, but not toxin B-induced, cell death.Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review.
P2860
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P2860
Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro
description
1995 nî lūn-bûn
@nan
1995 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Clostridium difficile toxin B ...... an colonic epithelium in vitro
@ast
Clostridium difficile toxin B ...... an colonic epithelium in vitro
@en
Clostridium difficile toxin B ...... an colonic epithelium in vitro
@nl
type
label
Clostridium difficile toxin B ...... an colonic epithelium in vitro
@ast
Clostridium difficile toxin B ...... an colonic epithelium in vitro
@en
Clostridium difficile toxin B ...... an colonic epithelium in vitro
@nl
prefLabel
Clostridium difficile toxin B ...... an colonic epithelium in vitro
@ast
Clostridium difficile toxin B ...... an colonic epithelium in vitro
@en
Clostridium difficile toxin B ...... an colonic epithelium in vitro
@nl
P2093
P2860
P356
P1476
Clostridium difficile toxin B ...... an colonic epithelium in vitro
@en
P2093
C Pothoulakis
E Cosentini
G Hamilton
J T LaMont
R Schiessel
P2860
P304
P356
10.1172/JCI117885
P407
P577
1995-05-01T00:00:00Z