Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+)
about
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertensionVoltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loopPrestin's anion transport and voltage-sensing capabilities are independentGating mechanism of BK (Slo1) channels: so near, yet so farInactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockadeGating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH terminiBeta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanismsBinding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathwayBK channels: multiple sensors, one activation gateDihydroxyeicosatrienoic acids are potent activators of Ca(2+)-activated K(+) channels in isolated rat coronary arterial myocytesSteady-state and closed-state inactivation properties of inactivating BK channelsVoltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) familyChloride-driven electromechanical phase lags at acoustic frequencies are generated by SLC26a5, the outer hair cell motor protein.Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain.A BK (Slo1) channel journey from molecule to physiology.Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel.Location of modulatory beta subunits in BK potassium channels.Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+.Cryo-EM structure of the open high-conductance Ca2+-activated K+ channelSensitivity of prestin-based membrane motor to membrane thickness.An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+.A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels.Complex voltage-dependent behavior of single unliganded calcium-sensitive potassium channels.Optimal estimation of ion-channel kinetics from macroscopic currents.Deconstructing thermodynamic parameters of a coupled system from site-specific observables.Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels.Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signalingAllosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels.β4-subunit increases Slo responsiveness to physiological Ca2+ concentrations and together with β1 reduces surface expression of Slo in hair cellsTemperature and voltage coupling to channel opening in transient receptor potential melastatin 8 (TRPM8).Setting the stage for molecular dissection of the regulatory components of BK channels.Single-channel kinetics of BK (Slo1) channels.Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry.Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating.Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channelCa2+-binding activity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+-dependent activation.Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications
P2860
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P2860
Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+)
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Allosteric voltage gating of p ...... rents in the absence of Ca(2+)
@ast
Allosteric voltage gating of p ...... rents in the absence of Ca(2+)
@en
type
label
Allosteric voltage gating of p ...... rents in the absence of Ca(2+)
@ast
Allosteric voltage gating of p ...... rents in the absence of Ca(2+)
@en
prefLabel
Allosteric voltage gating of p ...... rents in the absence of Ca(2+)
@ast
Allosteric voltage gating of p ...... rents in the absence of Ca(2+)
@en
P2093
P2860
P356
P1476
Allosteric voltage gating of p ...... rents in the absence of Ca(2+)
@en
P2093
P2860
P304
P356
10.1085/JGP.114.2.277
P577
1999-08-01T00:00:00Z