Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels - Wikidata - wikimedia - TriplyDB

Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels

Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels

http://www.wikidata.org/entity/Q36445008

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Aberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing loss Asymmetric Configurations and N-terminal Rearrangements in Connexin26 Gap Junction Channels A fully atomistic model of the Cx32 connexon Gating of Connexin Channels by transjunctional-voltage: Conformations and models of open and closed states.Conductance of connexin hemichannels segregates with the first transmembrane segment.Cosegregation of permeability and single-channel conductance in chimeric connexins.Pathogenetic role of the deafness-related M34T mutation of Cx26.Analysis of four connexin26 mutant gap junctions and hemichannels reveals variations in hexamer stability.Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channels.SCAM analysis of Panx1 suggests a peculiar pore structure Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50 The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannels.Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.The First Extracellular Domain Plays an Important Role in Unitary Channel Conductance of Cx50 Gap Junction Channels.Pore-lining residues identified by single channel SCAM studies in Cx46 hemichannels.A novel p.F206I mutation in Cx46 associated with autosomal dominant congenital cataract.Voltage-dependent conformational changes in connexin channels Glutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules.Connexinopathies: a structural and functional glimpse Connexin-based gap junction hemichannels: gating mechanisms Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function Accessing gap-junction channel structure-function relationships through molecular modeling and simulations Regulation of connexin hemichannels by monovalent cations.The NH2 terminus regulates voltage-dependent gating of CALHM ion channels.The gap junction cellular internet: connexin hemichannels enter the signalling limelight Molecular modeling and mutagenesis of gap junction channels.Properties of two cataract-associated mutations located in the NH2 terminus of connexin 46.Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gating.Identification and functional analysis of two novel connexin 50 mutations associated with autosome dominant congenital cataracts.The D50N mutation and syndromic deafness: altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions.Insights on the mechanisms of Ca(2+) regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y).Ion exclusion by sub-2-nm carbon nanotube pores.Gap junction channel structure in the early 21st century: facts and fantasies Antibodies targeting extracellular domain of connexins for studies of hemichannels Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels.The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates.Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain.

P2860

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P2860

Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels

http://www.wikidata.org/entity/Q36445008

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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Single-channel SCAM identifies ...... e domains of Cx46 hemichannels

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Single-channel SCAM identifies ...... e domains of Cx46 hemichannels

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Single-channel SCAM identifies ...... e domains of Cx46 hemichannels

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Single-channel SCAM identifies ...... e domains of Cx46 hemichannels

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Single-channel SCAM identifies ...... e domains of Cx46 hemichannels

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Single-channel SCAM identifies ...... e domains of Cx46 hemichannels

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P1433

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P356

P1433

The Journal of General Physiology

P1476

Single-channel SCAM identifies ...... e domains of Cx46 hemichannels

@en

P2093

E B Trexler

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F F Bukauskas

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J Kronengold

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T A Bargiello

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V K Verselis

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P2860

Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis

Connexin46 mutations in autosomal dominant congenital cataract.

Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel

A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant "zonular pulverulent" cataract, on chromosome 1q

Connexin mutations in X-linked Charcot-Marie-Tooth disease

Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes

Emerging issues of connexin channels: biophysics fills the gap.

Exchange of conductance and gating properties between gap junction hemichannels.

Identification of a pore lining segment in gap junction hemichannels.

P304

389-405

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scholarly article

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10.1085/JGP.200308861

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P433

4

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P478

122

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P577

2003-09-15T00:00:00Z

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P5875

10567205

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P698

12975451

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P921

transmembrane protein

P932

2233777

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