Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.
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A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channelsStructure and Rearrangements in the Carboxy-Terminal Region of SpIH ChannelsC-terminal Movement during Gating in Cyclic Nucleotide-modulated ChannelsStructural Basis for the cAMP-dependent Gating in the Human HCN4 ChannelLRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic StrengthTemperature affects voltage-sensitive conductances differentially in octopus cells of the mammalian cochlear nucleusStructure, dynamics and implied gating mechanism of a human cyclic nucleotide-gated channelDistal end of carboxyl terminus is not essential for the assembly of rat Eag1 potassium channelsThe murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotidescAMP Modulation of the cytoplasmic domain in the HCN2 channel investigated by molecular simulations.Distinct perinatal features of the hyperpolarization-activated non-selective cation current I(h) in the rat cortical plate.Double electron-electron resonance reveals cAMP-induced conformational change in HCN channels.Structure of the SthK carboxy-terminal region reveals a gating mechanism for cyclic nucleotide-modulated ion channelsThe disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change.The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path.Dynamic measurements for funny channels.Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.Molecular mechanism underlying phosphatidylinositol 4,5-bisphosphate-induced inhibition of SpIH channels.Ligand-binding domain subregions contributing to bimodal agonism in cyclic nucleotide-gated channelscAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.Highly conserved salt bridge stabilizes rigid signal patch at extracellular loop critical for surface expression of acid-sensing ion channels.Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel.Structural changes during HCN channel gating defined by high affinity metal bridges.Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6.Short-range molecular rearrangements in ion channels detected by tryptophan quenching of bimane fluorescence.Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides.Free-energy relationships in ion channels activated by voltage and ligand.Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides.Mutations at arginine 352 alter the pore architecture of CFTR.A secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channelsInsights on the mechanisms of Ca(2+) regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y).Disease-associated mutations in CNGB3 promote cytotoxicity in photoreceptor-derived cells.Two salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy.Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMPExtracellular domains play different roles in gap junction formation and docking compatibility.The enigmatic cytoplasmic regions of KCNH channels.HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.
P2860
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P2860
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.
@ast
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.
@en
type
label
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.
@ast
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.
@en
prefLabel
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.
@ast
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.
@en
P2860
P356
P1476
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.
@en
P2093
Kimberley B Craven
William N Zagotta
P2860
P304
P356
10.1085/JGP.200409178
P577
2004-12-01T00:00:00Z