Presenilins are required for maintenance of neural stem cells in the developing brain.
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Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunctionPartial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortexBmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birthGender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease.Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal developmentPresenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathwayPresenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling.The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortexNeddylation dysfunction in Alzheimer's disease.The γ-secretase complex: from structure to function.Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiationFamilial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice.Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteinsRepurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signalingPresenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulationCell cycle deregulation in the neurons of Alzheimer's disease.Presenilins in synaptic function and disease.Function and dysfunction of presenilinCancer stem cell targeting: are we there yet?Indirect regulation of presenilins in CREB-mediated transcription.Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases.Presenilin-1 regulates neural progenitor cell differentiation in the adult brain.An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.Increased adult neurogenesis associated with reactive astrocytosis occurs prior to neuron loss in a mouse model of neurodegenerative disease.The cellular composition of neurogenic periventricular zones in the adult zebrafish forebrain.
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P2860
Presenilins are required for maintenance of neural stem cells in the developing brain.
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
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2008年學術文章
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2008年學術文章
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name
Presenilins are required for maintenance of neural stem cells in the developing brain.
@ast
Presenilins are required for maintenance of neural stem cells in the developing brain.
@en
type
label
Presenilins are required for maintenance of neural stem cells in the developing brain.
@ast
Presenilins are required for maintenance of neural stem cells in the developing brain.
@en
prefLabel
Presenilins are required for maintenance of neural stem cells in the developing brain.
@ast
Presenilins are required for maintenance of neural stem cells in the developing brain.
@en
P2860
P356
P1476
Presenilins are required for maintenance of neural stem cells in the developing brain.
@en
P2093
Woo-Young Kim
P2860
P2888
P356
10.1186/1750-1326-3-2
P577
2008-01-08T00:00:00Z
P5875
P6179
1005741997