Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs. - Wikidata - wikimedia - TriplyDB

Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

http://www.wikidata.org/entity/Q36452421

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From selection hits to clinical leads: progress in aptamer discovery The structural diversity of artificial genetic polymers The steric hypothesis for DNA replication and fluorine hydrogen bonding revisited in light of structural data Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA The solution structure of double helical arabino nucleic acids (ANA and 2'F-ANA): effect of arabinoses in duplex-hairpin interconversion Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides 2′-Azido RNA, a Versatile Tool for Chemical Biology: Synthesis, X-ray Structure, siRNA Applications, Click Labeling The Conformationally Constrained N -Methanocarba-dT Analogue Adopts an Unexpected C4′- exo Sugar Pucker in the Structure of a DNA Hairpin Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2′-Fluoro RNA 2'-Fluoro RNA shows increased Watson-Crick H-bonding strength and stacking relative to RNA: evidence from NMR and thermodynamic data.siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering.Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.Evolution of thermophilic DNA polymerases for the recognition and amplification of C2'-modified DNA.2'Fluoro Modification Differentially Modulates the Ability of RNAs to Activate Pattern Recognition Receptors.Stabilization of i-motif structures by 2'-β-fluorination of DNA.Design of siRNA Therapeutics from the Molecular Scale Non-coding RNA and antisense RNA. Nature's trash or treasure?Endless: a purine-binding RNA motif that can be expressed in cells.A 5'-cap for DNA probes binding RNA target strands.Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity.Delivery of siRNAs to Dendritic Cells Using DEC205-Targeted Lipid Nanoparticles to Inhibit Immune Responses.Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides.Stacking up CRISPR against RNAi for therapeutic gene inhibition.Myeloid cells as orchestrators of the tumor microenvironment: novel targets for nanoparticular cancer therapy.Biological applications of xeno nucleic acids.The chemical evolution of oligonucleotide therapies of clinical utility.Therapeutic potential of chemically modified siRNA: Recent trends.mRNA knockdown by single strand RNA is improved by chemical modifications Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor 7.Advances in Lipid Nanoparticles for siRNA Delivery.Single-stranded microRNA mimics.Synthesis, duplex stabilization and structural properties of a fluorinated carbocyclic LNA analogue Intracellular stability of 2'-OMe-4'-thioribonucleoside modified siRNA leads to long-term RNAi effect Recombinant purine nucleoside phosphorylases from thermophiles: preparation, properties and activity towards purine and pyrimidine nucleosides.Synthesis and properties of 2'-O-neopentyl modified oligonucleotides.RNA interference for glioblastoma therapy: Innovation ladder from the bench to clinical trials.Synthesis and duplex-stabilizing properties of fluorinated N-methanocarbathymidine analogues locked in the C3'-endo conformation.Self-Transfecting Micellar RNA: Modulating Nanoparticle Cell Interactions via High Density Display of Small Molecule Ligands on Micelle Coronas.

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Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

http://www.wikidata.org/entity/Q36452421

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Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

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Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

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Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

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Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

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Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

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Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

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Angewandte Chemie International Edition

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Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

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Akin Akinc

http://www.w3.org/2001/XMLSchema#string

Emily M Greene

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Eriks Rozners

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June Qin

http://www.w3.org/2001/XMLSchema#string

Kallanthottathil G Rajeev

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Kathy Mills

http://www.w3.org/2001/XMLSchema#string

Klaus Charisse

http://www.w3.org/2001/XMLSchema#string

Lubomir Nechev

http://www.w3.org/2001/XMLSchema#string

Martin A Maier

http://www.w3.org/2001/XMLSchema#string

Matthias John

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P2860

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

The RNA-induced silencing complex: a versatile gene-silencing machine

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

RNA hydration: a detailed look

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics.

In vivo activity of nuclease-resistant siRNAs

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication.

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs.

The many roles for fluorine in medicinal chemistry.

Organic fluorine: odd man out.

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10.1002/ANIE.201006519

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