The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends
about
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathwayRibonucleotides in bacterial DNAStructure of bacterial LigD 3'-phosphoesterase unveils a DNA repair superfamilyStructures and activities of archaeal members of the LigD 3'-phosphoesterase DNA repair enzyme superfamilyStructural insights to the metal specificity of an archaeal member of the LigD 3'-phosphoesterase DNA repair enzyme familySolution structure and DNA-binding properties of the phosphoesterase domain of DNA ligase DM. tuberculosis Sliding β-Clamp Does Not Interact Directly with the NAD+ -Dependent DNA LigaseNoncanonical views of homology-directed DNA repairMicrohomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesisGap filling activities of Pseudomonas DNA ligase D (LigD) polymerase and functional interactions of LigD with the DNA end-binding Ku proteinA Sir2-like protein participates in mycobacterial NHEJBiochemical and Structural Characterisation of DNA Ligases from Bacteria and ArchaeaAdnAB: a new DSB-resecting motor-nuclease from mycobacteria.Characterization of the mycobacterial AdnAB DNA motor provides insights into the evolution of bacterial motor-nuclease machinesAn end-joining repair mechanism in Escherichia coli.Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection.Characterization of the roles of the catalytic domains of Mycobacterium tuberculosis ligase D in Ku-dependent error-prone DNA end joiningMycobacteria exploit three genetically distinct DNA double-strand break repair pathwaysCharacterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation.XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.Either non-homologous ends joining or homologous recombination is required to repair double-strand breaks in the genome of macrophage-internalized Mycobacterium tuberculosisDirect and inverted repeats elicit genetic instability by both exploiting and eluding DNA double-strand break repair systems in mycobacteria.Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair.Mycobacterium smegmatis RqlH defines a novel clade of bacterial RecQ-like DNA helicases with ATP-dependent 3'-5' translocase and duplex unwinding activitiesMycobacterium smegmatis SftH exemplifies a distinctive clade of superfamily II DNA-dependent ATPases with 3' to 5' translocase and helicase activitiesC-terminal low-complexity sequence repeats of Mycobacterium smegmatis Ku modulate DNA bindingA dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing.Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joiningRibonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates.C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repairMechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining.Multiplicity of DNA end resection machineries in chromosome break repairDomain requirements for DNA unwinding by mycobacterial UvrD2, an essential DNA helicase.Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D.Mutational analysis of Mycobacterium UvrD1 identifies functional groups required for ATP hydrolysis, DNA unwinding, and chemomechanical couplingMultiple and Variable NHEJ-Like Genes Are Involved in Resistance to DNA Damage in Streptomyces ambofaciens.Homologous recombination mediated by the mycobacterial AdnAB helicase without end resection by the AdnAB nucleasesPolymerases in nonhomologous end joining: building a bridge over broken chromosomes.Is non-homologous end-joining really an inherently error-prone process?
P2860
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P2860
The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
The pathways and outcomes of m ...... ructure of the broken DNA ends
@ast
The pathways and outcomes of m ...... ructure of the broken DNA ends
@en
type
label
The pathways and outcomes of m ...... ructure of the broken DNA ends
@ast
The pathways and outcomes of m ...... ructure of the broken DNA ends
@en
prefLabel
The pathways and outcomes of m ...... ructure of the broken DNA ends
@ast
The pathways and outcomes of m ...... ructure of the broken DNA ends
@en
P2860
P356
P1433
P1476
The pathways and outcomes of m ...... ructure of the broken DNA ends
@en
P2093
Jideofor Aniukwu
Michael S Glickman
P2860
P304
P356
10.1101/GAD.1631908
P577
2008-02-01T00:00:00Z