Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
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Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual ExperimentsA Multiscale Agent-Based in silico Model of Liver Fibrosis ProgressionPharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.A mechanistic model of drug-induced liver injury AIDS the interpretation of elevated liver transaminase levels in a phase I clinical trial.Computational approaches to analyse and predict small molecule transport and distribution at cellular and subcellular levelsSystems toxicology: from basic research to risk assessment.Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury.Risk factors for severe or fatal drug-induced liver injury from amoxicillin-clavulanic acid.Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling.Integrated Approaches to Testing and Assessment.Large-scale computational models of liver metabolism: How far from the clinics?A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure.Current Concepts in Drug-Induced Bile Salt Export Pump (BSEP) Interference.Modeling of xenobiotic transport and metabolism in virtual hepatic lobule models
P2860
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P2860
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
@ast
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
@en
type
label
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
@ast
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
@en
prefLabel
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
@ast
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
@en
P2093
P2860
P356
P1476
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches
@en
P2093
Brett A Howell
Courtney G Woods
Jeffrey L Woodhead
Lisl K M Shoda
Melvin E Andersen
Paul B Watkins
Qiang Zhang
Scott Q Siler
Yuching Yang
P2860
P356
10.3389/FPHYS.2012.00462
P577
2012-12-14T00:00:00Z