Functional interactions between Sae2 and the Mre11 complex.
about
DNA end resection: many nucleases make light workCOM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joiningCyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection.Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.Human CtIP mediates cell cycle control of DNA end resection and double strand break repairElevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway.A sequence-dependent exonuclease activity from Tetrahymena thermophila.End resection at double-strand breaks: mechanism and regulation.Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization.Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.The Rad50 coiled-coil domain is indispensable for Mre11 complex functionsSumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein.Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous RecombinationProcessing of DNA double-stranded breaks and intermediates of recombination and repair by Saccharomyces cerevisiae Mre11 and its stimulation by Rad50, Xrs2, and Sae2 proteins.Mechanism and regulation of DNA end resection in eukaryotesNovel insights into RAD51 activity and regulation during homologous recombination and DNA replicationThe MRE11 complex: starting from the ends.Taming the tiger by the tail: modulation of DNA damage responses by telomeres.DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.Structural studies of DNA end detection and resection in homologous recombination.CtIP/Ctp1/Sae2, molecular form fit for function.Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage.Replication checkpoint: tuning and coordination of replication forks in s phase.HDACs link the DNA damage response, processing of double-strand breaks and autophagy.When two is not enough: a CtIP tetramer is required for DNA repair by Homologous Recombination.Genetic separation of Sae2 nuclease activity from Mre11 nuclease functions in budding yeast.Fumarase is involved in DNA double-strand break resection through a functional interaction with Sae2.Regulatory control of DNA end resection by Sae2 phosphorylation
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P2860
Functional interactions between Sae2 and the Mre11 complex.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Functional interactions between Sae2 and the Mre11 complex.
@ast
Functional interactions between Sae2 and the Mre11 complex.
@en
type
label
Functional interactions between Sae2 and the Mre11 complex.
@ast
Functional interactions between Sae2 and the Mre11 complex.
@en
prefLabel
Functional interactions between Sae2 and the Mre11 complex.
@ast
Functional interactions between Sae2 and the Mre11 complex.
@en
P2093
P2860
P1433
P1476
Functional interactions between Sae2 and the Mre11 complex
@en
P2093
Clifford Weil
Hee-Sook Kim
Jacob C Harrison
Mike Reger
Sangeetha Vijayakumar
P2860
P304
P356
10.1534/GENETICS.107.081331
P407
P577
2008-02-01T00:00:00Z