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DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.

DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.

http://www.wikidata.org/entity/Q37742898

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DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1 Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications Modulation of DNA damage and repair pathways by human tumour viruses The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors.The DNA Damage Response: Making It Safe to Play with Knives Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response Mechanisms for Structural Variation in the Human Genome And-1 is required for homologous recombination repair by regulating DNA end resection.And-1 coordinates with CtIP for efficient homologous recombination and DNA damage checkpoint maintenance Unrepaired DNA damage facilitates elimination of uniparental chromosomes in interspecific hybrid cells.SUMOylation and de-SUMOylation in response to DNA damage.The MRN complex in double-strand break repair and telomere maintenance.DNA double-strand break signaling and human disorders.CDK1 plays an important role in the maintenance of pluripotency and genomic stability in human pluripotent stem cells Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.Loss of autophagy causes a synthetic lethal deficiency in DNA repair.BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.DNA end resection is needed for the repair of complex lesions in G1-phase human cells.The COP9 signalosome is vital for timely repair of DNA double-strand breaks.Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation.Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1.The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair.Sharpening the ends for repair: mechanisms and regulation of DNA resection.A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin.PCNA promotes processive DNA end resection by Exo1.CtIP is required for DNA damage-dependent induction of P21.Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression?Epigenetic regulation of genomic integrity.Pathways for genome integrity in G2 phase of the cell cycle.The Fanconi anemia ID2 complex: dueling saxes at the crossroads.

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DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.

http://www.wikidata.org/entity/Q37742898

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 03 May 2010

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.

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DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.

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DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.

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DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.

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DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.

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DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.

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J.TCB.2010.04.002

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Trends in Cell Biology

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DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.

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Julie M Bailis

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Zhongsheng You

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P2860

Characterization of a carboxy-terminal BRCA1 interacting protein

Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

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402-409

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10.1016/J.TCB.2010.04.002

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