Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
about
Protein C anticoagulant and cytoprotective pathwaysDifferential signaling by protease-activated receptors: implications for therapeutic targeting.Comparative response of platelet fV and plasma fV to activated protein C and relevance to a model of acute traumatic coagulopathy.Activated protein C action in inflammationSignal transduction by protease-activated receptorsThe IL-8 protease SpyCEP is detrimental for Group A Streptococcus host-cells interaction and biofilm formation.The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11bEndothelial cell protein C receptor: a multiliganded and multifunctional receptorAllosteric modulation of protease-activated receptor signaling.Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection.Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor.Streptococcal SpeB cleaved PAR-1 suppresses ERK phosphorylation and blunts thrombin-induced platelet aggregation.The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteasesActivated protein C up-regulates procoagulant tissue factor activity on endothelial cells by shedding the TFPI Kunitz 1 domain.Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)Activated protein C: biased for translation.Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects.Protease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury.Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway.Caveolae are required for protease-selective signaling by protease-activated receptor-1.Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.Activated protein C in sepsis: the promise of nonanticoagulant activated protein C.Growing insights into the potential benefits and risks of activated protein C administration in sepsis: a review of preclinical and clinical studies.Protease-activated receptors and prostaglandins in inflammatory lung disease.Protective mechanisms of activated protein C in severe inflammatory disorders.Vascular and dendritic cell coagulation signaling in sepsis progression.Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease.Activated protein C in the treatment of acute lung injury and acute respiratory distress syndrome.New insights into modulation of thrombin formation.Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1.
P2860
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P2860
Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
description
2007 nî lūn-bûn
@nan
2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
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2007年學術文章
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2007年學術文章
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name
Activated protein C-cleaved pr ...... en in the presence of thrombin
@ast
Activated protein C-cleaved pr ...... en in the presence of thrombin
@en
type
label
Activated protein C-cleaved pr ...... en in the presence of thrombin
@ast
Activated protein C-cleaved pr ...... en in the presence of thrombin
@en
prefLabel
Activated protein C-cleaved pr ...... en in the presence of thrombin
@ast
Activated protein C-cleaved pr ...... en in the presence of thrombin
@en
P2093
P2860
P1433
P1476
Activated protein C-cleaved pr ...... en in the presence of thrombin
@en
P2093
Clemens Feistritzer
Lawrence F Brass
Matthias Riewald
Reto A Schuepbach
P2860
P304
P356
10.1182/BLOOD-2007-09-113076
P407
P577
2007-12-18T00:00:00Z