Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis - Wikidata - wikimedia - TriplyDB

Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis

Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis

http://www.wikidata.org/entity/Q36482941

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Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells Regulation of Bim in Health and Disease A protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos Roles of caveolin-1 on anoikis resistance in non small cell lung cancer Anoikis resistance: an essential prerequisite for tumor metastasis Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis.Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression The virus-induced protein APOBEC3G inhibits anoikis by activation of Akt kinase in pancreatic cancer cells.Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells.TLR4 ligand/H₂O₂ enhances TGF-β1 signaling to induce metastatic potential of non-invasive breast cancer cells by activating non-Smad pathways.Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis.β3 integrin promotes TGF-β1/H2O2/HOCl-mediated induction of metastatic phenotype of hepatocellular carcinoma cells by enhancing TGF-β1 signaling.Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines.High Prevalence of the BIM Deletion Polymorphism in Young Female Breast Cancer in an East Asian Country.Understanding micrometastatic disease and Anoikis resistance in ewing family of tumors and osteosarcoma.Mechanisms of cancer cell metastasis to the bone: a multistep process.Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis.Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway.Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology.Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells.Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737.p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells.Imperatorin sensitizes anoikis and inhibits anchorage-independent growth of lung cancer cells.Pokemon silencing leads to Bim-mediated anoikis of human hepatoma cell QGY7703.Pleiotropic action of AP-1 in v-Src-transformed cells.SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis.The first EGF domain of coagulation factor IX attenuates cell adhesion and induces apoptosis.A signal-based method for finding driver modules of breast cancer metastasis to the lung.miR-301a promotes pancreatic cancer cell proliferation by directly inhibiting Bim expression.Cycloartobiloxanthone Induces Human Lung Cancer Cell Apoptosis via Mitochondria-dependent Apoptotic Pathway.Deconstructing Signaling Pathways in Cancer for Optimizing Cancer Combination Therapies.Priming stem cells with protein kinase C activator enhances early stem cell-chondrocyte interaction by increasing adhesion molecules

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P2860

Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis

http://www.wikidata.org/entity/Q36482941

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Anoikis, initiated by Mcl-1 de ...... deregulated during oncogenesis

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Francis Y Lee

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Hirohito Yamaguchi

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Hong-Gang Wang

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Kapil N Bhalla

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Nicholas T Woods

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

Disruption of epithelial cell-matrix interactions induces apoptosis

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

Spatial and temporal changes in Bax subcellular localization during anoikis

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

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