Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A. - Wikidata - wikimedia - TriplyDB

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.

http://www.wikidata.org/entity/Q36485104

about

Tumor Targeting and Drug Delivery by Anthrax Toxin The development of immunoconjugates for targeted cancer therapy Mapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidate Removing T-cell epitopes with computational protein design.Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate.Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo.Paclitaxel synergizes with exposure time adjusted CD22-targeting immunotoxins against B-cell malignancies.Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes.Discovery of mesothelin and exploiting it as a target for immunotherapy.Improving the safety of cell therapy products by suicide gene transfer GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer Antiviral activity of a single-domain antibody immunotoxin binding to glycoprotein D of herpes simplex virus 2.Methylation-associated partial down-regulation of mesothelin causes resistance to anti-mesothelin immunotoxins in a pancreatic cancer cell line.Depletion of T cell epitopes in lysostaphin mitigates anti-drug antibody response and enhances antibacterial efficacy in vivo.Developing a Novel Gene-Delivery Vector System Using the Recombinant Fusion Protein of Pseudomonas Exotoxin A and Hyperthermophilic Archaeal Histone HPhA.High throughput cytotoxicity screening of anti-HER2 immunotoxins conjugated with antibody fragments from phage-displayed synthetic antibody libraries Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A.Recombinant Immunotoxin with T-cell Epitope Mutations That Greatly Reduce Immunogenicity for Treatment of Mesothelin-Expressing Tumors.A novel far-red fluorescent xenograft model of ovarian carcinoma for preclinical evaluation of HER2-targeted immunotoxins.Immunogenicity of therapeutic recombinant immunotoxins.Safeguarding clinical translation of pluripotent stem cells with suicide genes.Scratching the Surface: Resurfacing Proteins to Endow New Properties and Function.Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity.Design and In Vivo Characterization of Immunoconjugates Targeting HIV gp160.Rational design of low immunogenic anti CD25 recombinant immunotoxin for T cell malignancies by elimination of T cell epitopes in PE38.Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems A high throughput MHC II binding assay for quantitative analysis of peptide epitopes.Immunogenicity of antibody drug conjugates: bioanalytical methods and monitoring strategy for a novel therapeutic modality.Development of a strategy and computational application to select candidate protein analogues with reduced HLA binding and immunogenicity.Population-specific design of de-immunized protein biotherapeutics.Addressing the Immunogenicity of the Cargo and of the Targeting Antibodies with a Focus on Demmunized Bacterial Toxins and on Antibody-Targeted Human Effector Proteins.Improving the in vivo efficacy of an anti-Tac (CD25) immunotoxin by Pseudomonas exotoxin A domain II engineering.Recombinant immunotoxins with albumin-binding domains have long half-lives and high antitumor activity.Antiviral Immunotoxin Against Bovine herpesvirus-1: Targeted Inhibition of Viral Replication and Apoptosis of Infected Cell.Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia.

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P2860

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.

http://www.wikidata.org/entity/Q36485104

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Identification and elimination ...... sed on Pseudomonas exotoxin A.

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Identification and elimination ...... sed on Pseudomonas exotoxin A.

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Proceedings of the National Academy of Sciences of the United States of America

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Identification and elimination ...... ased on Pseudomonas exotoxin A

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Aaron N Vassall

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David J Venzon

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Ira Pastan

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Jaime A Eberle

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Kwong Y Tsang

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Richard Beers

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Ronit Mazor

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P2860

Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations

Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution

Immunoproteomic identification of human T cell antigens of Mycobacterium tuberculosis that differentiate healthy contacts from tuberculosis patients.

Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift

Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes.

T cell-dependent B cell activation.

Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates.

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.

Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.

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23213206

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