Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.
about
Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologicsDangerous liaisons: how the immune system deals with factor VIIIMapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidateComputationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate.Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loadsEpitope recognition in HLA-DR3 transgenic mice immunized to TSH-R protein or peptides.Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo.CHOPPI: a web tool for the analysis of immunogenicity risk from host cell proteins in CHO-based protein production.C3d adjuvant effects are mediated through the activation of C3d-specific autoreactive T cellsEngineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses.Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A.EpiSweep: Computationally Driven Reengineering of Therapeutic Proteins to Reduce Immunogenicity While Maintaining Function.Design and analysis of immune-evading enzymes for ADEPT therapy.Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase.Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.Immunogenicity of therapeutic recombinant immunotoxins.Progress toward inducing immunologic tolerance to factor VIII.Strategies for reducing inhibitor formation in severe haemophilia.Engineering less immunogenic and antigenic FVIII proteins.A close insight to factor VIII inhibitor in the congenital hemophilia A.A high throughput MHC II binding assay for quantitative analysis of peptide epitopes.Of [Hamsters] and men: a new perspective on host cell proteins.Structure-based redesign of proteins for minimal T-cell epitope contentLimited promiscuity of HLA-DRB1 presented peptides derived of blood coagulation factor VIII.T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire.T-cell epitope content comparison (EpiCC) of swine H1 influenza A virus hemagglutinin.Development of a strategy and computational application to select candidate protein analogues with reduced HLA binding and immunogenicity.Population-specific design of de-immunized protein biotherapeutics.Addressing the Immunogenicity of the Cargo and of the Targeting Antibodies with a Focus on Demmunized Bacterial Toxins and on Antibody-Targeted Human Effector Proteins.
P2860
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P2860
Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.
@ast
Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.
@en
type
label
Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.
@ast
Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.
@en
prefLabel
Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.
@ast
Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.
@en
P2093
P2860
P1433
P1476
Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo
@en
P2093
Chang Song
David W Scott
Ryan Tassone
William D Martin
P2860
P304
P356
10.1016/J.CLIM.2011.11.010
P577
2011-12-08T00:00:00Z