about
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcriptionReprogramming of energy metabolism as a driver of agingRestructuring of the dinucleotide-binding fold in an NADP(H) sensor proteinWld(S) reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NADWhat have novel imaging techniques revealed about metabolism in the aging brain?Imaging mitochondria in living corneal endothelial cells using autofluorescence microscopy.Metabolic interrogation as a tool to optimize chemotherapeutic regimens.Vincristine attenuates N-methyl-N'-nitro-N-nitrosoguanidine-induced poly-(ADP) ribose polymerase activity in cardiomyocytes.Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson's disease.Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer.Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice.Oxidative stress and PARP activation mediate the NADH-induced decrease in glioma cell survival.Permeability transition pore-dependent and PARP-mediated depletion of neuronal pyridine nucleotides during anoxia and glucose deprivation.Intracellular redox state revealed by in vivo (31) P MRS measurement of NAD(+) and NADH contents in brains.Genetically encoded fluorescent indicator for imaging NAD(+)/NADH ratio changes in different cellular compartments.The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian hostPre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models.Oxidative stress and NAD+ in ischemic brain injury: current advances and future perspectives.The coordination of nuclear and mitochondrial communication during aging and calorie restrictionβ-Lapachone, a substrate of NAD(P)H:quinone oxidoreductase, induces anti-inflammatory heme oxygenase-1 via AMP-activated protein kinase activation in RAW264.7 macrophages.Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders.In vivo (31) P MRS assessment of intracellular NAD metabolites and NAD(+) /NADH redox state in human brain at 4 T.Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair.Postischemic oxidative stress promotes mitochondrial metabolic failure in neurons and astrocytes.NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice.The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors.Roles of NAD (+) , PARP-1, and Sirtuins in Cell Death, Ischemic Brain Injury, and Synchrotron Radiation X-Ray-Induced Tissue Injury.Mitochondrial energy metabolism and redox signaling in brain aging and neurodegenerationNon-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes.NAD+ Attenuates Bilirubin-Induced Hyperexcitation in the Ventral Cochlear Nucleus by Inhibiting Excitatory Neurotransmission and Neuronal Excitability.Multifunctional roles of NAD⁺ and NADH in astrocytes.NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism.Effects of Kynurenine Pathway Metabolites on Intracellular NAD Synthesis and Cell Death in Human Primary Astrocytes and Neurons.Targeting NAMPT for Therapeutic Intervention in Cancer and Inflammation: Structure-Based Drug Design and Biological Screening.Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights.Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
NAD+ and NADH in cellular functions and cell death.
@ast
NAD+ and NADH in cellular functions and cell death.
@en
type
label
NAD+ and NADH in cellular functions and cell death.
@ast
NAD+ and NADH in cellular functions and cell death.
@en
prefLabel
NAD+ and NADH in cellular functions and cell death.
@ast
NAD+ and NADH in cellular functions and cell death.
@en
P356
P1476
NAD+ and NADH in cellular functions and cell death.
@en
P2093
Weihai Ying
P304
P356
10.2741/2038
P577
2006-09-01T00:00:00Z