Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug. - Wikidata - wikimedia - TriplyDB

Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug.

Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug.

http://www.wikidata.org/entity/Q36486772

about

Thapsigargin--from Thapsia L. to mipsagargin Animal models and the tumor microenvironment: studies of tumor-host symbiosis Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment Carcinoma-associated fibroblasts: orchestrating the composition of malignancy Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment The Combination of Three Natural Compounds Effectively Prevented Lung Carcinogenesis by Optimal Wound Healing Interstitial fluid flow in cancer: implications for disease progression and treatment.Therapeutic strategies for targeting the ovarian tumor stroma.Fibroblast activating protein-α expression in squamous cell carcinoma of the esophagus in primary and irradiated tumors: the use of archival FFPE material for molecular techniques Pharmacokinetics and toxicology of a fibroblast activation protein (FAP)-activated prodrug in murine xenograft models of human cancer.Clinical Implications of Marker Expression of Carcinoma-Associated Fibroblasts (CAFs) in Patients with Epithelial Ovarian Carcinoma After Treatment with Neoadjuvant Chemotherapy.Elevated CXCL1 expression in breast cancer stroma predicts poor prognosis and is inversely associated with expression of TGF-β signaling proteins The role of epithelial plasticity in prostate cancer dissemination and treatment resistance Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion Fibroblast activation protein overexpression and clinical implications in solid tumors: a meta-analysis.Dipeptidyl-peptidase IV activity is correlated with colorectal cancer prognosis.Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer.Seneca Valley Virus 3Cpro Substrate Optimization Yields Efficient Substrates for Use in Peptide-Prodrug Therapy Stromal Expression of Fibroblast Activation Protein Alpha (FAP) Predicts Platinum Resistance and Shorter Recurrence in patients with Epithelial Ovarian Cancer.Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers.Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome.The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases.Fibroblast activation protein is dispensable in the anti-influenza immune response in mice.A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in mice Optical imaging of tumor microenvironment Targeting inhibition of fibroblast activation protein-α and prolyl oligopeptidase activities on cells common to metastatic tumor microenvironments Prolyl endopeptidase activity is correlated with colorectal cancer prognosis.Heterotypic cellular interactions in the ovarian tumor microenvironment: biological significance and therapeutic implications.Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity.Imaging aspects of the tumor stroma with therapeutic implications.Stromal Androgen Receptor in Prostate Cancer Development and Progression Heterogeneity in Cancer Metabolism: New Concepts in an Old Field.Genetic regulation and potentially therapeutic application of cancer-associated fibroblasts in oral cancer.Cell mates: paracrine and stromal targets for prostate cancer therapy.Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales.Molecular mechanism underlying the tumor-promoting functions of carcinoma-associated fibroblasts.Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics.Can Targeting Stroma Pave the Way to Enhanced Antitumor Immunity and Immunotherapy of Solid Tumors?Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy.

P2860

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P2860

Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug.

http://www.wikidata.org/entity/Q36486772

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Targeting carcinoma-associated ...... ion protein-activated prodrug.

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type

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Targeting carcinoma-associated ...... ion protein-activated prodrug.

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Targeting carcinoma-associated ...... ion protein-activated prodrug.

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Journal of the National Cancer Institute

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Targeting carcinoma-associated ...... ion protein-activated prodrug.

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P2093

D Marc Rosen

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Hao Wang

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John T Isaacs

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Samuel R Denmeade

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W Nathaniel Brennen

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P2860

Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts

Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers

Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy

Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer

A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer

FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor

Friends or foes - bipolar effects of the tumour stroma in cancer

Molecular characterization of the tumor microenvironment in breast cancer.

Purification, identification and characterisation of seprase from bovine serum.

Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast.

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1320-1334

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10.1093/JNCI/DJS336

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17

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104

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22911669

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3529592

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