The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.
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Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteinsThe centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegansNovel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartmentThe primary cilium as a cellular signaling center: lessons from diseaseThe hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formationThe base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalizationCompartments within a compartment: what C. elegans can tell us about ciliary subdomain composition, biogenesis, function, and diseaseThe polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells.Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary SignalingKIAA0556 is a novel ciliary basal body component mutated in Joubert syndromeMKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition ZoneThe small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesisMKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesisTransition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexesTMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndromeNephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathyNPHP4 is necessary for normal photoreceptor ribbon synapse maintenance and outer segment formation, and for sperm development.CiliopathiesCentriolar remodeling underlies basal body maturation during ciliogenesis in Caenorhabditis elegans.Nephronophthisis: disease mechanisms of a ciliopathy.Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4.Specific alpha- and beta-tubulin isotypes optimize the functions of sensory Cilia in Caenorhabditis elegansCSPP is a ciliary protein interacting with Nephrocystin 8 and required for cilia formation.Functional specialization of sensory cilia by an RFX transcription factor isoformNPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone.The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans.Assessing the pathogenic potential of human Nephronophthisis disease-associated NPHP-4 missense mutations in C. elegans.Drosophila chibby is required for basal body formation and ciliogenesis but not for Wg signaling.The ciliary transition zone: from morphology and molecules to medicineA Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4.Ciliogenesis in Caenorhabditis elegans requires genetic interactions between ciliary middle segment localized NPHP-2 (inversin) and transition zone-associated proteins.Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neuronsFormation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundanceWhole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis.Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control.Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport.What drives cell morphogenesis: a look inside the vertebrate photoreceptor
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P2860
The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.
@ast
The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.
@en
type
label
The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.
@ast
The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.
@en
prefLabel
The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.
@ast
The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.
@en
P2093
P2860
P356
P1476
The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.
@en
P2093
Andrew R Jauregui
Ken C Q Nguyen
Maureen M Barr
P2860
P304
P356
10.1083/JCB.200707090
P407
P577
2008-03-03T00:00:00Z