Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension. - Wikidata - wikimedia - TriplyDB

Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.

Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.

http://www.wikidata.org/entity/Q36494495

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The bestrophin- and TMEM16A-associated Ca(2+)- activated Cl(–) channels in vascular smooth muscles Cellular functions of TMEM16/anoctamin Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2 Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation.Down-regulation of TRPM8 in pulmonary arteries of pulmonary hypertensive rats.Hypoxia augments the calcium-activated chloride current carried by anoctamin-1 in cardiac vascular endothelial cells of neonatal mice.Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC.Calcium-activated chloride channels anoctamin 1 and 2 promote murine uterine smooth muscle contractility.Identification and characterization of a novel promoter for the human ANO1 gene regulated by the transcription factor signal transducer and activator of transcription 6 (STAT6)Construction of gene clusters resembling genetic causal mechanisms for common complex disease with an application to young-onset hypertension The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes.Anoctamin-1 in the juvenile rat urinary bladder.Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle.Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer.Effects of new-generation inhibitors of the calcium-activated chloride channel anoctamin 1 on slow waves in the gastrointestinal tract.New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit?Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries.TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension.Sphingosine and FTY720 modulate pacemaking activity in interstitial cells of Cajal from mouse small intestine.Spin biochemistry modulates reactive oxygen species (ROS) production by radio frequency magnetic fields.Cl⁻ channels in smooth muscle cells.Calcium homeostasis and sensitization in pulmonary arterial smooth muscle.Proteomics of pulmonary hypertension: could personalized profiles lead to personalized medicine?Regulation of vascular tone and arterial blood pressure: role of chloride transport in vascular smooth muscle.Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1).Increased TMEM16A Involved in Alveolar Fluid Clearance After Lipopolysaccharide Stimulation.ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer Negative News: Cl- and HCO3- in the Vascular Wall.Molecular, biophysical, and pharmacological properties of calcium-activated chloride channels.An integrated assessment of histopathological changes of the enteric neuromuscular compartment in experimental colitis.Serotonin receptors take the TRiPV4 highway in chronic hypoxic pulmonary hypertension. Focus on "TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension Inhibitory role of phosphatidylinositol 4,5-bisphosphate on TMEM16A-encoded calcium-activated chloride channels in rat pulmonary artery.TMEM16A regulates portal vein smooth muscle cell proliferation in portal hypertension.CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A.

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Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.

http://www.wikidata.org/entity/Q36494495

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2012年學術文章

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Increased TMEM16A-encoded calc ...... d with pulmonary hypertension.

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Increased TMEM16A-encoded calc ...... d with pulmonary hypertension.

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Increased TMEM16A-encoded calc ...... d with pulmonary hypertension.

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Increased TMEM16A-encoded calc ...... d with pulmonary hypertension.

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Increased TMEM16A-encoded calc ...... d with pulmonary hypertension.

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Increased TMEM16A-encoded calc ...... d with pulmonary hypertension.

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AJPCELL.00044.2012

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American Journal of Physiology - Cell Physiology

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Increased TMEM16A-encoded calc ...... d with pulmonary hypertension.

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Abigail S Forrest

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Alison J Davis

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John Joyce

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Linda Ye

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Marissa L Huebner

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Michael Wiwchar

http://www.w3.org/2001/XMLSchema#string

Natalie Freitas

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Ramon J Ayon

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Talia C Joyce

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P2860

Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels

Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies

TMEM16A/anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells

The transmembrane protein TMEM16A is required for normal development of the murine trachea

TMEM16A confers receptor-activated calcium-dependent chloride conductance

Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.

Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA.

Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies

Chloride channels and their functional roles in smooth muscle tone in the vasculature.

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C1229-43

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10.1152/AJPCELL.00044.2012

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12

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303

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Iain A Greenwood

Dayue Darrel Duan

Normand R. Leblanc

Cherie A. Singer

Maria L. Valencik

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2012-10-03T00:00:00Z

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232008727

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23034390

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arterial hypertension

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3532492

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