Deregulated Cdk5 activity is involved in inducing Alzheimer's disease - Wikidata - wikimedia - TriplyDB

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

http://www.wikidata.org/entity/Q36494716

about

Current Research Therapeutic Strategies for Alzheimer's Disease Treatment Alzheimer's Disease: Mechanism and Approach to Cell Therapy Physiological and pathological phosphorylation of tau by Cdk5 Synaptic dysfunction and septin protein family members in neurodegenerative diseases A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5 Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality Hippocampal gene expression meta-analysis identifies aging and age-associated spatial learning impairment (ASLI) genes and pathways.Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice.Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice Altered distribution of the EphA4 kinase in hippocampal brain tissue of patients with Alzheimer's disease correlates with pathology Prenatal alcohol exposure alters p35, CDK5 and GSK3β in the medial frontal cortex and hippocampus of adolescent mice Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons.Protein interaction module-assisted function X (PIMAX) approach to producing challenging proteins including hyperphosphorylated tau and active CDK5/p25 kinase complex Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid.Cdk5r1 Overexpression Induces Primary β-Cell Proliferation.Analysis of the Inhibitory Elements in the p5 Peptide Fragment of the CDK5 Activator, p35, CDKR1 Protein.TFP5 prevents 1-methyl-4-phenyl pyridine ion-induced neurotoxicity in mouse cortical neurons.Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice.Protein profiles associated with context fear conditioning and their modulation by memantine.Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing.Involvement of 'stress-response' kinase pathways in Alzheimer's disease progression.Tau acts as a mediator for Alzheimer's disease-related synaptic deficits.Cdk5 regulates multiple cellular events in neural development, function and disease.Copper as a key regulator of cell signalling pathways.Protein phosphorylation in neurodegeneration: friend or foe?The Role of Cdk5 in Alzheimer's Disease.Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in Alzheimer's disease model.Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration.Treatment strategies in Alzheimer's disease: a review with focus on selenium supplementation.Perspectives for treating Alzheimer's disease: a review on promising pharmacological substances.Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain.Cdk5-Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease.Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein.The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease.Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle Activation Gene Network Construction from Microarray Data Identifies a Key Network Module and Several Candidate Hub Genes in Age-Associated Spatial Learning Impairment.

P2860

Q26765530-A5C352EF-F744-4A79-B5B7-DB658B7B128D Q26778149-0A8B4FFD-774F-4293-93BD-506AC44897C1 Q26860395-51B641A4-44F3-4ADC-A2FE-04A8F7D40982 Q27026829-19E50843-5ABE-4401-9B01-AD270D4FC6EE Q28388637-4EDDC031-2F3B-492F-96E2-4FFDA151D4F1 Q28396052-81497E94-D0E7-4A1C-8EFB-48B8BFF974B5 Q28834464-55CF0161-92FD-4A6C-82CE-A564C9C252ED Q30572403-C4FC4AAF-6E28-40D3-9A27-5B7E61845A98 Q31123604-B69BBA7C-D85C-4DDB-BF3C-D20E6058B6EF Q33702585-A5AAEA3F-6DC5-4236-8888-E8BA9089EF60 Q33865294-603D6541-05A1-4D9D-87F2-D84F5EF5C287 Q34109035-B65FDA92-B86B-4617-989B-0C698EB88701 Q34200115-E497605D-F396-4961-ADC7-E17832306A96 Q34776047-36E6D056-FEB5-41CE-8FB9-1155E48929B9 Q34884230-FBEDAEF5-D86D-4C48-975B-AAA68C0666F8 Q35669383-2DF3F1CD-8DB2-4507-9114-01B215B07E7B Q36405673-2CF3D406-EBE4-447F-9D74-01D612A4DA03 Q37053942-30C02C05-BCBE-44A6-9071-B4AC2176C8E2 Q37288349-8B3B8B4F-9F21-46DF-B9F1-B5343617969B Q37289231-D5D0EB64-0359-4611-82BE-803EAA27F53C Q37457439-19873648-208D-46E2-9E07-FDEEBD0913C5 Q37687443-2E3F7CA9-DA4A-4331-928C-CF9A0D069B8B Q37718997-309B58AE-E308-442F-AC8C-C20F7B8C3C02 Q38202756-C2732D2C-C470-466F-88D8-9D20077F5CBB Q38203031-A586C3CA-CD2E-421C-AA72-318B34A117E6 Q38213140-37F1DADC-2A9A-4AFD-8B7F-3934B190150C Q38213536-6CB99676-6C6D-4B05-B7EE-1B0326C1F99B Q38214594-6D4824F8-C12F-48B6-9497-26758A5FACB6 Q38557958-681DDAD1-14CE-4B19-AB4B-FB6B7C82F80C Q38656547-2A7502C6-E150-4697-8C3B-96665E03BC54 Q38732547-ED1F4272-0B66-49DE-B0F2-757702383554 Q38928927-D62F3A15-EDFD-4EB9-B904-005BC734B9C9 Q38936146-269E14BE-12F4-4A34-B3B9-92470C5FBE9B Q39043782-7A04F7BF-79FD-4F28-AB4D-763AA5AC027B Q39304793-11B15729-E1FA-40BF-901E-231BCF9BA225 Q40801428-13957D65-C95B-4781-BDDD-755D35C4E032 Q41780599-351920A7-6FC6-41DA-BE06-585DB643FBBA Q41828232-818FCCD7-EC99-4D21-88A2-135672C1EEA5 Q42369804-EE25ACF5-D33B-441D-98D5-1E1D26C5F065 Q42654233-85D1EF17-A118-4359-87C4-84F438270162

P2860

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

http://www.wikidata.org/entity/Q36494716

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

@ast

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

@en

type

label

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

@ast

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

@en

prefLabel

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

@ast

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

@en

P1433

Q36494716-61AB024F-C71A-4F56-A448-664421D4B566

P1476

Q36494716-4E4EEED5-9F16-4999-9455-50B10BEB8F4A

P2093

Q36494716-61229393-852B-4851-8D32-19592108BDA5

Q36494716-6C3B060D-4914-410A-8969-4580A8224657

Q36494716-CBAE0C8D-B82B-4ADC-99BE-CEF468FF9D97

P2860

Q36494716-08EDFD59-740D-4E53-BFE5-D751E9D641CF

Q36494716-12B87CD5-2A7B-41F8-8C95-05CE865D2F31

Q36494716-14C6FBF7-EC02-4730-AD76-0DDAAAB9CE93

Q36494716-15675B16-8717-41A4-9B5E-7D55C83B9A5B

Q36494716-15BEABB6-D443-4968-8701-9B6037F35A9B

Q36494716-164C6945-F5C6-4631-8BA6-C80C2E2AA2CB

Q36494716-199F97C0-EA00-4CFA-A52D-6B60973E62FB

Q36494716-1A27C4A7-97B0-4537-8160-332122243177

Q36494716-1F65D4EC-7410-4563-A2EE-B9CC8B8B8338

Q36494716-21F992A7-22F2-406E-978A-55F38034513B

P304

Q36494716-D128F51E-EEDA-4352-930F-9214864F6E18

P31

Q36494716-9436E411-908E-40BB-9EEE-68C1F2ACCDBA

P356

Q36494716-A68751EE-3243-4CE9-81DA-A74BBE046CDE

P433

Q36494716-3F85455D-8428-41C8-8527-78BFC3544FA7

P478

Q36494716-14ABA6E2-3566-41C4-94D0-DCA9B6D29B9D

P577

Q36494716-B05F3880-B1D3-4CC6-80FD-4EA48941FD23

P5875

Q36494716-BA164B70-F0C4-460D-BE74-2BDCA250DF48

P698

Q36494716-2068B7E8-1A49-4DDC-A7A3-81487D78265A

P921

Q36494716-DA5A0BEA-5575-47C9-B546-597C4B240998

P932

Q36494716-7381FD0D-AFE5-430B-A47A-4CA8F0D59EB6

P356

J.ARCMED.2012.10.015

P1433

Archives of Medical Research

P1476

Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

@en

P2093

Harish C Pant

http://www.w3.org/2001/XMLSchema#string

Susan Skuntz

http://www.w3.org/2001/XMLSchema#string

Varsha Shukla

http://www.w3.org/2001/XMLSchema#string

P2860

Tau pathology in Alzheimer disease and other tauopathies

A family of human cdc2-related protein kinases

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

P304

655-662

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.ARCMED.2012.10.015

http://www.w3.org/2001/XMLSchema#string

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

43

http://www.w3.org/2001/XMLSchema#string

P577

2012-11-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

233394470

http://www.w3.org/2001/XMLSchema#string

P698

23142263

http://www.w3.org/2001/XMLSchema#string

P921

Alzheimer's disease

P932

3532552

http://www.w3.org/2001/XMLSchema#string