Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.
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Role of Hedgehog Signaling Pathway in NASHMorphogen rules: design principles of gradient-mediated embryo patterningContext-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapyLanguage Impairments in ASD Resulting from a Failed Domestication of the Human BrainUniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactionsSonic hedgehog signaling in the postnatal brain.An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines.Modular evolution of DNA-binding preference of a Tbrain transcription factor provides a mechanism for modifying gene regulatory networksA theoretical framework for the regulation of Shh morphogen-controlled gene expressionVertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties.Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube.The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.Reconstruction of the gene regulatory network involved in the sonic hedgehog pathway with a potential role in early development of the mouse brainResponse to Nodal morphogen gradient is determined by the kinetics of target gene induction.Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms.Spatiotemporal analysis of different mechanisms for interpreting morphogen gradientsSox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo.Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signalingA Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary.Identification and Validation of Novel Hedgehog-Responsive Enhancers Predicted by Computational Analysis of Ci/Gli Binding Site DensityComputational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathwayPostmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2.A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressorsHEDGEHOG/GLI-E2F1 axis modulates iASPP expression and function and regulates melanoma cell growth.Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional ProgramsAn ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1.Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning.Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification.Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafishUnderstanding Mechanisms of GLI-Mediated Transcription during Craniofacial Development and Disease Using the Ciliopathic Mutant, talpid2.An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth.A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud.Transcriptional regulation of graded Hedgehog signalingHedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction.Morphogen interpretation: concentration, time, competence, and signaling dynamicsNucleolar and spindle associated protein 1 promotes the aggressiveness of astrocytoma by activating the Hedgehog signaling pathway.Low affinity binding site clusters confer hox specificity and regulatory robustness.Spatiotemporal regulation of GLI target genes in the mammalian limb bud.Arx together with FoxA2, regulates Shh floor plate expression.Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution.
P2860
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P2860
Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Neural-specific Sox2 input and ...... hh-directed neural patterning.
@ast
Neural-specific Sox2 input and ...... hh-directed neural patterning.
@en
type
label
Neural-specific Sox2 input and ...... hh-directed neural patterning.
@ast
Neural-specific Sox2 input and ...... hh-directed neural patterning.
@en
prefLabel
Neural-specific Sox2 input and ...... hh-directed neural patterning.
@ast
Neural-specific Sox2 input and ...... hh-directed neural patterning.
@en
P2093
P2860
P356
P1433
P1476
Neural-specific Sox2 input and ...... hh-directed neural patterning.
@en
P2093
Anastasia Vedenko
Andrew P McMahon
Bradley E Bernstein
Jan Philipp Junker
José-Manuel Baizabal
Kevin A Peterson
Leila Shokri
Martha L Bulyk
Matthew McFarlane
Tarjei Mikkelsen
P2860
P304
P356
10.1101/GAD.207142.112
P577
2012-12-01T00:00:00Z