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MDM2 and MDMX: Alone and together in regulation of p53MDM2, MDMX and p53 in oncogenesis and cancer therapyMicroRNA-34a modulates MDM4 expression via a target site in the open reading framep53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors.MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.XI-006 induces potent p53-independent apoptosis in Ewing sarcoma.Whole genome sequence analysis links chromothripsis to EGFR, MDM2, MDM4, and CDK4 amplification in glioblastoma.Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cellsTargeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer.Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation.Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy.Functions of MDMX in the modulation of the p53-response.Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy.MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond.Mdm2 protein expression is strongly associated with survival in malignant pleural mesothelioma.p53 and RAD9, the DNA Damage Response, and Regulation of Transcription Networks.Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry.Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation.Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE.MiR-370 promotes apoptosis in colon cancer by directly targeting MDM4.TP53 pathway analysis in paediatric Burkitt lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases.The Roles of MDM2 and MDMX in Cancer.Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5MDMX under stress: the MDMX-MDM2 complex as stress signals hub
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Regulation of MDMX expression by mitogenic signaling.
@ast
Regulation of MDMX expression by mitogenic signaling.
@en
type
label
Regulation of MDMX expression by mitogenic signaling.
@ast
Regulation of MDMX expression by mitogenic signaling.
@en
prefLabel
Regulation of MDMX expression by mitogenic signaling.
@ast
Regulation of MDMX expression by mitogenic signaling.
@en
P2093
P2860
P356
P1476
Regulation of MDMX expression by mitogenic signaling.
@en
P2093
Daniele M Gilkes
Domenico Coppola
Gary W Reuther
Jiandong Chen
Timothy Yeatman
P2860
P304
P356
10.1128/MCB.01633-07
P407
P577
2008-01-02T00:00:00Z