Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling.
about
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptorGPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M currentCannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritisMarijuana, Spice 'herbal high', and early neural development: implications for rescheduling and legalizationLigand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1Computational analysis of the CB1 carboxyl-terminus in the receptor-G protein complexOptodynamic simulation of β-adrenergic receptor signalling.Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice.CB1 allosteric modulator Org27569 is an antagonist/inverse agonist of ERK1/2 signaling.JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonistType 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons.Psychopharmacology of the endocannabinoids: far beyond anandamide.The cannabinoid type-1 receptor carboxyl-terminus, more than just a tail.CP47,497-C8 and JWH073, commonly found in 'Spice' herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonistsCB(1) cannabinoid receptors and their associated proteins.AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner.Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.Functional selectivity in CB(2) cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB(2) ligands.CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain.Hormonal status and age differentially affect tolerance to the disruptive effects of delta-9-tetrahydrocannabinol (Δ(9)-THC) on learning in female rats.Mice Expressing a "Hyper-Sensitive" Form of the Cannabinoid Receptor 1 (CB1) Are Neither Obese Nor DiabeticOvarian hormones and chronic administration during adolescence modify the discriminative stimulus effects of delta-9-tetrahydrocannabinol (Δ⁹-THC) in adult female rats.Molecular Targets of Cannabidiol in Neurological DisordersAn animal model of female adolescent cannabinoid exposure elicits a long-lasting deficit in presynaptic long-term plasticity.Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal.Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88.CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.Binding between a distal C-terminus fragment of cannabinoid receptor 1 and arrestin-2.Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor.Regulation of CB1 cannabinoid receptor internalization by a promiscuous phosphorylation-dependent mechanism.Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action.Cannabinoid CB1 receptor-dependent long-term depression in autaptic excitatory neuronsCannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling.Mastering tricyclic ring systems for desirable functional cannabinoid activity.CB1 receptor-mediated signaling underlies the hippocampal synaptic, learning, and memory deficits following treatment with JWH-081, a new component of spice/K2 preparationsMutation of putative GRK phosphorylation sites in the cannabinoid receptor 1 (CB1R) confers resistance to cannabinoid tolerance and hypersensitivity to cannabinoids in miceβ-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia.The Multiple Waves of Cannabinoid 1 Receptor Signaling.Arresting the Development of Addiction: The Role of β-Arrestin 2 in Drug Abuse.
P2860
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P2860
Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Rapid CB1 cannabinoid receptor ...... f ERK1/2 MAP kinase signaling.
@ast
Rapid CB1 cannabinoid receptor ...... f ERK1/2 MAP kinase signaling.
@en
type
label
Rapid CB1 cannabinoid receptor ...... f ERK1/2 MAP kinase signaling.
@ast
Rapid CB1 cannabinoid receptor ...... f ERK1/2 MAP kinase signaling.
@en
prefLabel
Rapid CB1 cannabinoid receptor ...... f ERK1/2 MAP kinase signaling.
@ast
Rapid CB1 cannabinoid receptor ...... f ERK1/2 MAP kinase signaling.
@en
P2860
P921
P1433
P1476
Rapid CB1 cannabinoid receptor ...... of ERK1/2 MAP kinase signaling
@en
P2093
Christopher S Kearn
Tanya L Daigle
P2860
P356
10.1016/J.NEUROPHARM.2007.06.005
P50
P577
2007-06-26T00:00:00Z