MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
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Kir6.2 mutations causing neonatal diabetes prevent endocytosis of ATP-sensitive potassium channels.Noble gas xenon is a novel adenosine triphosphate-sensitive potassium channel openerA mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetesMechanisms of action of glucagon-like peptide 1 in the pancreasThe Nucleotide-Binding Sites of SUR1: A Mechanistic ModelThe carboxyl termini of K(ATP) channels bind nucleotidesATP-sensitive potassium channels in capillaries isolated from guinea-pig heartExpression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heartKir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactionsCharacterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridgeGenetic variations in magnesium-related ion channels may affect diabetes risk among African American and Hispanic American womenEngineered Kir6.2 mutations that correct the trafficking defect of K(ATP) channels caused by specific SUR1 mutationsAltered functional properties of KATP channel conferred by a novel splice variant of SUR1.ATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit.ATP-sensitive potassium channelopathies: focus on insulin secretionMutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide bindingA gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome.The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATPThe ligand-sensitive gate of a potassium channel lies close to the selectivity filter.ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic beta-cell KATP channelsA Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating.Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamideDirect interaction of Na-azide with the KATP channel.Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetesATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transferAdjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism.ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart.Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.KATP Channels in the Cardiovascular System.Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits.Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibitionOpen state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP.Structural and functional determinants of conserved lipid interaction domains of inward rectifying Kir6.2 channelsRole for SUR2A ED domain in allosteric coupling within the K(ATP) channel complex.Ligand-dependent linkage of the ATP site to inhibition gate closure in the KATP channelA mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.
P2860
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P2860
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
@ast
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
@en
type
label
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
@ast
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
@en
prefLabel
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
@ast
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
@en
P2860
P50
P356
P1476
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit
@en
P2093
F M Ashcroft
P2860
P304
P356
10.1073/PNAS.95.12.7185
P407
P577
1998-06-01T00:00:00Z