about
Functional analysis of missense variants in the TRESK (KCNK18) K channelHow highly charged anionic lipids bind and regulate ion channelsStructure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gatingControl of KirBac3.1 Potassium Channel Gating at the Interface between Cytoplasmic DomainsK2P channel gating mechanisms revealed by structures of TREK-2 and a complex with ProzacTruncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptorAssignment of KATP-1, the cardiac ATP-sensitive potassium channel gene (KCNJ5), to human chromosome 11q24A novel KCNA1 mutation identified in an Italian family affected by episodic ataxia type 1Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating propertiesKir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalisFunctional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domainsA hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel.Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channelsInward rectification in KATP channels: a pH switch in the pore.State-dependent network connectivity determines gating in a K+ channelMolecular determinants of KATP channel inhibition by ATP.A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.Novel phenotype associated with a mutation in the KCNA1(Kv1.1) geneRenal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome.Conformational changes during the gating of a potassium channel revealed by structural mass spectrometry.Molecular simulation studies of hydrophobic gating in nanopores and ion channels.De novo point mutations in patients diagnosed with ataxic cerebral palsy.Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide TransportMolecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits.A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.Hydrophobic gating in ion channelsRespiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16).Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.In vitro reconstitution of eukaryotic ion channels using droplet interface bilayers.Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.Insights into the structural nature of the transition state in the Kir channel gating pathway.Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel.A BEST example of channel structure annotation by molecular simulation.Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channelNon-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels.State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1Asymmetric mechanosensitivity in a eukaryotic ion channel.The effects of stretch activation on ionic selectivity of the TREK-2 K2P K+ channel.
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
@en
հետազոտող
@hy
name
Stephen J. Tucker
@ast
Stephen J. Tucker
@en
Stephen J. Tucker
@es
Stephen J. Tucker
@sl
type
label
Stephen J. Tucker
@ast
Stephen J. Tucker
@en
Stephen J. Tucker
@es
Stephen J. Tucker
@sl
prefLabel
Stephen J. Tucker
@ast
Stephen J. Tucker
@en
Stephen J. Tucker
@es
Stephen J. Tucker
@sl
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P1153
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P2798
P31
P496
0000-0001-8996-2000