Oxidative metabolites of curcumin poison human type II topoisomerases.
about
Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIαCatalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanismUnraveling curcumin degradation: autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione.Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIαSynthesis of novel C5-curcuminoid-fatty acid conjugates and mechanistic investigation of their anticancer activityEffects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases.Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.Degradation of Curcumin: From Mechanism to Biological ImplicationsInhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives.Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα.Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases.Facile synthesis of deuterated and [(14) C]labeled analogs of vanillin and curcumin for use as mechanistic and analytical tools.Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons.Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer.Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research.Redox modulation of curcumin stability: Redox active antioxidants increase chemical stability of curcumin.Upregulation of extrinsic apoptotic pathway in curcumin-mediated antiproliferative effect on human pancreatic carcinogenesis.The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites.Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes.Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα.Stability and anti-inflammatory activity of the reduction-resistant curcumin analog, 2,6-dimethyl-curcumin.Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy.
P2860
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P2860
Oxidative metabolites of curcumin poison human type II topoisomerases.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Oxidative metabolites of curcumin poison human type II topoisomerases.
@ast
Oxidative metabolites of curcumin poison human type II topoisomerases.
@en
type
label
Oxidative metabolites of curcumin poison human type II topoisomerases.
@ast
Oxidative metabolites of curcumin poison human type II topoisomerases.
@en
prefLabel
Oxidative metabolites of curcumin poison human type II topoisomerases.
@ast
Oxidative metabolites of curcumin poison human type II topoisomerases.
@en
P2093
P2860
P356
P1433
P1476
Oxidative metabolites of curcumin poison human type II topoisomerases.
@en
P2093
Adam C Ketron
Claus Schneider
Neil Osheroff
Odaine N Gordon
P2860
P304
P356
10.1021/BI3014455
P407
P577
2012-12-26T00:00:00Z