Aiolos promotes TH17 differentiation by directly silencing Il2 expression - Wikidata - wikimedia - TriplyDB

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

http://www.wikidata.org/entity/Q36520966

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Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells Th17 plasticity and its changes associated with inflammatory bowel disease The immunogenetics of primary biliary cirrhosis: A comprehensive review The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response Aryl hydrocarbon receptor control of adaptive immunity From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines Toward understanding the role of aryl hydrocarbon receptor in the immune system: current progress and future trends Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease.The Ikaros family of zinc-finger proteins The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells Genetic and epigenetic fine mapping of causal autoimmune disease variants MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis Solving the genetic puzzle of systemic lupus erythematosus.miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation Modeling genome-wide dynamic regulatory network in mouse lungs with influenza infection using high-dimensional ordinary differential equations.Human IL-6RhiTIGIT- CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile.Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells.Ubiquitous points of control over regulatory T cells.IL-21 induces IL-22 production in CD4+ T cells.Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo.The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.Transcriptional and epigenetic regulation of T-helper lineage specification.Role and therapeutic value of dendritic cells in central nervous system autoimmunity.Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation.SIRT1 deacetylates RORγt and enhances Th17 cell generation IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling.CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.Differential regulation of Th17 and T regulatory cell differentiation by aryl hydrocarbon receptor dependent xenobiotic response element dependent and independent pathways Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells CD101 inhibits the expansion of colitogenic T cells.Transcriptional regulatory networks for CD4 T cell differentiation.Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21 E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation.Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.Aryl hydrocarbon receptor: Linking environment to immunity.Helios Controls a Limited Subset of Regulatory T Cell Functions

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P2860

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

http://www.wikidata.org/entity/Q36520966

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

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Aiolos promotes TH17 differentiation by directly silencing Il2 expression

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type

label

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

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Aiolos promotes TH17 differentiation by directly silencing Il2 expression

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Aiolos promotes TH17 differentiation by directly silencing Il2 expression

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Aiolos promotes TH17 differentiation by directly silencing Il2 expression

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Nature Immunology

P1476

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

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P2093

Ada Yeste

http://www.w3.org/2001/XMLSchema#string

Chen Zhu

http://www.w3.org/2001/XMLSchema#string

Deepak Kumar

http://www.w3.org/2001/XMLSchema#string

Evan J Burns

http://www.w3.org/2001/XMLSchema#string

Francisco J Quintana

http://www.w3.org/2001/XMLSchema#string

Hulin Jin

http://www.w3.org/2001/XMLSchema#string

John Seavitt

http://www.w3.org/2001/XMLSchema#string

Katia Georgopoulos

http://www.w3.org/2001/XMLSchema#string

Manu Rangachari

http://www.w3.org/2001/XMLSchema#string

Meghan Nadeau

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P2860

Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

IL-17 and Th17 Cells

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

Induction of intestinal Th17 cells by segmented filamentous bacteria

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770-777

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10.1038/NI.2363

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8

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P478

13

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2012-07-01T00:00:00Z

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228103067

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22751139

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3541018

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