Protein quality control acts on folding intermediates to shape the effects of mutations on organismal fitness.
about
Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population geneticsComparing protein folding in vitro and in vivo: foldability meets the fitness challengeRecent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterizationIndividual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli.A model of proteostatic energy cost and its use in analysis of proteome trends and sequence evolutionFitness Trade-Offs Determine the Role of the Molecular Chaperonin GroEL in Buffering MutationsViewing protein fitness landscapes through a next-gen lens.The molecular chaperone DnaK is a source of mutational robustnessThe Role of Evolutionary Selection in the Dynamics of Protein Structure Evolution.Molecular Determinants of Mutant Phenotypes, Inferred from Saturation Mutagenesis DataA comprehensive, high-resolution map of a gene's fitness landscapeThe binary protein-protein interaction landscape of Escherichia coliOpposing effects of folding and assembly chaperones on evolvability of Rubisco.Reconstructed Ancestral Enzymes Impose a Fitness Cost upon Modern Bacteria Despite Exhibiting Favourable Biochemical Properties.Latent effects of Hsp90 mutants revealed at reduced expression levels.Variation in the fitness effects of mutations with population density and size in Escherichia coliThermal stabilization of dihydrofolate reductase using monte carlo unfolding simulations and its functional consequences.Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in BacteriaBiophysical principles predict fitness landscapes of drug resistance.BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity.Alanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function.Modulating protein stability - directed evolution strategies for improved protein function.Quantifying and understanding the fitness effects of protein mutations: Laboratory versus natureRole of auxiliary proteins in Rubisco biogenesis and function.Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations.De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.Systems-level response to point mutations in a core metabolic enzyme modulates genotype-phenotype relationship.Selection on metabolic pathway function in the presence of mutation-selection-drift balance leads to rate-limiting steps that are not evolutionarily stable.Is catalytic activity of chaperones a selectable trait for the emergence of heat shock response?A "fuzzy"-logic language for encoding multiple physical traits in biomolecules.Catalysis of protein folding by chaperones accelerates evolutionary dynamics in adapting cell populationsA Simple Model of Protein Domain Swapping in Crowded Cellular Environments.Thermosensitivity of growth is determined by chaperone-mediated proteome reallocation.The burst-phase folding intermediate of ribonuclease H changes conformation over evolutionary history.Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics.Low cost, microcontroller based heating device for multi-wavelength differential scanning fluorimetry.Optimization of lag phase shapes the evolution of a bacterial enzyme.Phylogenetic divergence of cell biological features.TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy
P2860
Q26861515-BBB51DF8-26E7-4D7A-8E6A-5571404B4087Q26991933-D3B6AF83-6F39-4F67-BF76-B97ADF49EF9AQ26996528-1DCFC21C-4BEE-49D6-91CE-6211F92AD6B4Q27320857-C659C5B5-D95E-4D9B-B02A-91709B66E2DAQ28540274-FA8397FF-1035-4E1E-8FEB-DB6130F0AEE8Q28607448-C3A5FE73-8A90-47AB-AA1D-B6A1D8A855E6Q30367833-0CF659AE-87EA-4DD0-B412-7DD389FBDF08Q30391567-1B8C23F1-D8D7-4514-8740-6ACC1D2C958DQ30401012-DB202BB0-4306-40A4-AA1D-E39C98A2487BQ31123704-54E38EFB-4B0E-4C5C-9C27-4C0B0A7795C9Q33654337-3BDC77BD-ABF8-47ED-922E-282F9F229FB0Q34010755-07E7AD4E-794D-4684-BCE3-7B691A8A88F2Q34456547-C4D8917C-AC4B-4BAE-AD53-D67AF2365F6FQ34493140-313CE6E9-05AE-4CFB-A5E0-7090246CAC04Q34795559-56DEA795-5BC3-43F9-B02A-604BA5457996Q35224374-46B3E47D-85A8-4541-9909-CD7ED3D623DDQ35612683-9980CDBF-2308-4DFF-B7C8-74689B6C8E36Q35814404-51B6FE77-A673-4866-9B2E-B8B97FDEECEFQ36710493-C9D728D6-4DB5-429F-B86B-1AFB3472EEDCQ36880214-A4E2AE83-C65A-4B32-84C4-4B0A1DA17B6AQ37524872-74588B20-2563-45EE-BC56-07D77BEA0BBEQ37633562-5FFDB1E1-4F6A-4474-B319-25FF00987C47Q38109676-AA2DCC41-4893-4CBC-AB3A-2C57EFC0F448Q38787151-92D14DA6-BD20-40B9-BDC3-FC2DA5AF6F53Q38850428-1E69DCF4-887A-4777-967B-C1CC851F3B7BQ38997863-D256A504-A092-43F5-9CA1-1F361A57E14FQ40066647-A49C3A40-25D9-4926-B3F3-D3290B933BA3Q40170200-377ED9FA-E281-4843-9B4C-5B336D7D7F2FQ41841882-39A63F53-A78A-4154-B0F4-54655C4715F1Q41853435-A3E56F4D-A08F-48F9-9B11-878D2D86CA43Q41973906-FAF2F0B6-4D3D-4B4A-9B2D-8D5F89CF988EQ42050933-155578C5-BCCB-4177-890C-177BFC81A0EEQ42576606-2A9B8416-65E6-42B9-8175-1A671569BCB7Q46138830-94D6D7B5-FB48-4DC3-A100-C2965541C4C7Q46160796-8376447E-67B0-4EC1-BC27-77455E5EA964Q47135067-C108CE72-77A2-4789-A805-395995F826A7Q48181112-4A59BC3B-9084-406A-B213-643A79A3A129Q54150482-118DBD24-C492-4996-A70F-5A2E18AF3CC1Q55438253-DA1318A2-2D2F-448D-AB24-E8A639F22035Q58704576-E37D7CBA-6026-4348-A755-CD7BD8DB4326
P2860
Protein quality control acts on folding intermediates to shape the effects of mutations on organismal fitness.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Protein quality control acts o ...... tations on organismal fitness.
@ast
Protein quality control acts o ...... tations on organismal fitness.
@en
type
label
Protein quality control acts o ...... tations on organismal fitness.
@ast
Protein quality control acts o ...... tations on organismal fitness.
@en
prefLabel
Protein quality control acts o ...... tations on organismal fitness.
@ast
Protein quality control acts o ...... tations on organismal fitness.
@en
P2860
P50
P1433
P1476
Protein quality control acts o ...... tations on organismal fitness.
@en
P2093
Jingwen Zhou
Wanmeng Mu
P2860
P304
P356
10.1016/J.MOLCEL.2012.11.004
P577
2012-12-06T00:00:00Z