Biophysical principles predict fitness landscapes of drug resistance.

Biophysical principles predict fitness landscapes of drug resistance.

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http://www.wikidata.org/entity/Q36710493
Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target InteractionsSponge Microbiota Are a Reservoir of Functional Antibiotic Resistance Genes.Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.Beyond the Hypercube: Evolutionary Accessibility of Fitness Landscapes with Realistic Mutational Networks.Perspective: Quantum mechanical methods in biochemistry and biophysics.Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity.Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations.Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints.Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer.Selecting among three basic fitness landscape models: Additive, multiplicative and stickbreaking.Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.Increased substrate affinity in the Escherichia coli L28R dihydrofolate reductase mutant causes trimethoprim resistance.Optimization of lag phase shapes the evolution of a bacterial enzyme.Predicting evolution.Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence From in Vitro Genetics and Computer Simulations.
P2860

Biophysical principles predict fitness landscapes of drug resistance.

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http://www.wikidata.org/entity/Q36710493
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Biophysical principles predict fitness landscapes of drug resistance.
@ast
Biophysical principles predict fitness landscapes of drug resistance.
@en
type
label
Biophysical principles predict fitness landscapes of drug resistance.
@ast
Biophysical principles predict fitness landscapes of drug resistance.
@en
prefLabel
Biophysical principles predict fitness landscapes of drug resistance.
@ast
Biophysical principles predict fitness landscapes of drug resistance.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
Biophysical principles predict fitness landscapes of drug resistance
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932