LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage
about
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) familyLRP-1: a checkpoint for the extracellular matrix proteolysisDevelopment of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.Differential effects of caveolin-1 and -2 knockdown on aqueous outflow and altered extracellular matrix turnover in caveolin-silenced trabecular meshwork cells.Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.Cancer and embryo expression protein 65 promotes cancer cell growth and metastasis.Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)Arnica montana Stimulates Extracellular Matrix Gene Expression in a Macrophage Cell Line Differentiated to Wound-Healing PhenotypeA Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active OligomersEmerging Roles of ADAMTSs in Angiogenesis and Cancer.Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 bIL-1β promotes ADAMTS enzyme-mediated aggrecan degradation through NF-κB in human intervertebral disc.Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3.Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple MechanismsInhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.Early response of mouse joint tissue to noninvasive knee injury suggests treatment targets.Identification of LRP-1 as an endocytosis and recycling receptor for β1-integrin in thyroid cancer cells.Early changes in the knee of healer and non-healer mice following non-invasive mechanical injury.A Dual Role of Upper Zone of Growth Plate and Cartilage Matrix-Associated Protein in Human and Mouse Osteoarthritic Cartilage: Inhibition of Aggrecanases and Promotion of Bone Turnover.Interaction with macrophages attenuates Equine Fibroblast-Like Synoviocyte ADAMTS5 (aggrecanase-2) gene expression following inflammatory stimulation.Role of ADAMTS (A Disintegrin and Metalloproteinase With Thrombospondin Motifs)-5 in Aortic Dilatation and Extracellular Matrix Remodeling.Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes.Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor
P2860
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P2860
LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
LRP-1-mediated endocytosis reg ...... DAMTS-5 in articular cartilage
@ast
LRP-1-mediated endocytosis reg ...... DAMTS-5 in articular cartilage
@en
type
label
LRP-1-mediated endocytosis reg ...... DAMTS-5 in articular cartilage
@ast
LRP-1-mediated endocytosis reg ...... DAMTS-5 in articular cartilage
@en
prefLabel
LRP-1-mediated endocytosis reg ...... DAMTS-5 in articular cartilage
@ast
LRP-1-mediated endocytosis reg ...... DAMTS-5 in articular cartilage
@en
P2093
P2860
P356
P1433
P1476
LRP-1-mediated endocytosis reg ...... DAMTS-5 in articular cartilage
@en
P2093
Christopher L Murphy
Dudley K Strickland
Hideaki Nagase
Kazuhiro Yamamoto
Linda Troeberg
Michele Pelosi
Simone D Scilabra
P2860
P304
P356
10.1096/FJ.12-216671
P407
P577
2012-10-11T00:00:00Z