Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation. - Wikidata - wikimedia - TriplyDB

Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.

Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.

http://www.wikidata.org/entity/Q36534424

about

The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis Mitochondria, calcium and cell death: a deadly triad in neurodegeneration A chemical screen probing the relationship between mitochondrial content and cell size A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis Chemical approaches to nuclear receptors in metabolism High-Throughput RT-PCR for small-molecule screening assays 5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis Oxidants and Ca+2 induce PGC-1alpha degradation through calpain.Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury Therapeutic targeting of the mitochondrial dysfunction in septic acute kidney injury.Transient upregulation of PGC-1alpha diminishes cardiac ischemia tolerance via upregulation of ANT1.Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization PGC-1 coactivators regulate MITF and the tanning response.Sinulolides A-H, new cyclopentenone and butenolide derivatives from soft coral Sinularia sp.A small-molecule inducer of PDX1 expression identified by high-throughput screening.Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced vascular endothelial growth factor (VEGF) expression in non-small cell lung cancer.PGC-1α regulates normal and pathological angiogenesis in the retina A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver.PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle Peroxisome proliferator-activated-γ coactivator-1α-mediated mitochondrial biogenesis is important for hematopoietic recovery in response to stress.The role of exercise and PGC1alpha in inflammation and chronic disease.Energy metabolism in heart failure and remodelling.Minireview: the PGC-1 coactivator networks: chromatin-remodeling and mitochondrial energy metabolism Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age.Molecular determinants of brown adipocyte formation and function.Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?PGC-1 coactivators and skeletal muscle adaptations in health and disease.Exercise and muscle dysfunction in COPD: implications for pulmonary rehabilitation.Genetic models of PGC-1 and glucose metabolism and homeostasis Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor γ coactivator 1α.PGC-1 coactivators in cardiac development and disease Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.PGC-1 alpha regulates HO-1 expression, mitochondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid.Bioactivities of six sterols isolated from marine invertebrates.Molecules modulating gene transcription during muscle wasting in cancer, sepsis, and other critical illness.Angiogenesis. Targeting vascular sprouts.

P2860

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P2860

Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.

http://www.wikidata.org/entity/Q36534424

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Gene expression-based screenin ...... and oxidative phosphorylation.

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Gene expression-based screenin ...... and oxidative phosphorylation.

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type

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Gene expression-based screenin ...... and oxidative phosphorylation.

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Gene expression-based screenin ...... and oxidative phosphorylation.

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Gene expression-based screenin ...... and oxidative phosphorylation.

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Gene expression-based screenin ...... and oxidative phosphorylation.

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PNAS.0800979105

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Proceedings of the National Academy of Sciences of the United States of America

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Gene expression-based screenin ...... and oxidative phosphorylation.

@en

P2093

Bridget K Wagner

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Dina Laznik

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Jessica Chinsomboon

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Yanhong Ma

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Zoltan Arany

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P2860

Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

Functional discovery via a compendium of expression profiles.

Activation of PPARgamma coactivator-1 through transcription factor docking

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

Biological control through regulated transcriptional coactivators

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

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4721-4726

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12

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105

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Bruce Spiegelman

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5505807

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phosphorylation

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2290788

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