The development of resistance to methotrexate in a mouse melanoma cell line. I. Characterisation of the dihydrofolate reductases and chromosomes in sensitive and resistant cells.
about
Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell linesMithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo.On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.Human chromosome analysis in 24 cases of primary carcinoma of the large intestine: contribution of the G-banding technique.Paradoxical response of malignant melanoma to methotrexate in vivo and in vitro.Gene amplification accompanies low level increases in the activity of dihydrofolate reductase in antifolate-resistant Chinese hamster lung cells containing abnormally banding chromosomes.Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells.Selective amplification of polymorphic dihydrofolate reductase gene loci in Chinese hamster lung cells.Gene amplification in methotrexate-resistant mouse cells. IV. Different DNA sequences are amplified in different resistant lines.Expression of the amplified domain in human neuroblastoma cellsLoss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells.Specific DNA sequence amplification in human neuroblastoma cellsStructure and function of repetitive DNA in eukaryotes.Measurement of gene number for seed storage proteins in Pisum.Dihydrofolate reductase gene amplification-associated shift of differentiation in methotrexate-adapted HT-29 cells.Molecular biology and the clinician.
P2860
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P2860
The development of resistance to methotrexate in a mouse melanoma cell line. I. Characterisation of the dihydrofolate reductases and chromosomes in sensitive and resistant cells.
description
1979 nî lūn-bûn
@nan
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
1979年论文
@zh
1979年论文
@zh-cn
name
The development of resistance ...... sensitive and resistant cells.
@ast
The development of resistance ...... sensitive and resistant cells.
@en
type
label
The development of resistance ...... sensitive and resistant cells.
@ast
The development of resistance ...... sensitive and resistant cells.
@en
prefLabel
The development of resistance ...... sensitive and resistant cells.
@ast
The development of resistance ...... sensitive and resistant cells.
@en
P2093
P356
P1433
P1476
The development of resistance ...... sensitive and resistant cells.
@en
P2093
C J Bostock
C Tyler-Smith
N G Harding
P M Mounts
P M Walker
P2888
P304
P356
10.1007/BF00292270
P577
1979-01-01T00:00:00Z