PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth. - Wikidata - wikimedia - TriplyDB

PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth.

PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth.

http://www.wikidata.org/entity/Q36544764

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Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal Renal Cancer Stem Cells: Characterization and Targeted Therapies Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds Multiple myeloma cancer stem cells Targeting Strategies for Renal Cell Carcinoma: From Renal Cancer Cells to Renal Cancer Stem Cells Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities.Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia.HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance.Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models.Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells.Liquid-based three-dimensional tumor models for cancer research and drug discovery.α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice.Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer.Plasma microRNA panels to diagnose pancreatic cancer: Results from a multicenter study Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer.Cyr61-positive cancer stem-like cells enhances distal metastases of pancreatic cancer Gli promotes epithelial-mesenchymal transition in human lung adenocarcinomas Resistance to Cell Death and Its Modulation in Cancer Stem Cells.Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment.SNORA74B gene silencing inhibits gallbladder cancer cells by inducing PHLPP and suppressing Akt/mTOR signaling.Hedgehog inhibitor sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice Downregulation of BZW2 inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway.Endoplasmic reticulum stress could induce autophagy and apoptosis and enhance chemotherapy sensitivity in human esophageal cancer EC9706 cells by mediating PI3K/Akt/mTOR signaling pathway.USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met.Cancer stem cell signaling pathways.Targeting cancer stem cells for chemoprevention of pancreatic cancer.A New View of Pathway-Driven Drug Resistance in Tumor Proliferation.EMT reversal in human cancer cells after IR knockdown in hyperinsulinemic mice.Independent and core pathways in oncogenic KRAS signaling.BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity.MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX)miR-21 modulates the effect of EZH2 on the biological behavior of human lung cancer stem cells in vitro.Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression.Sanguinarine inhibits pancreatic cancer stem cell characteristics by inducing oxidative stress and suppressing sonic hedgehog-Gli-Nanog pathway.GOLPH2, a gene downstream of ras signaling, promotes the progression of pancreatic ductal adenocarcinoma.LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis.mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.

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P2860

PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth.

http://www.wikidata.org/entity/Q36544764

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2015 nî lūn-bûn

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PI3K/AKT/mTOR and sonic hedgeh ...... racteristics and tumor growth.

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Jay Sharma

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Karan P Singh

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Narinder Sharma

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Rajesh Nanta

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Rakesh K Srivastava

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Sharmila Shankar

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Sumedha Gunewardena

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P2860

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

The Lin28/let-7 axis regulates glucose metabolism

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms

MicroRNA biogenesis pathways in cancer

Mechanisms of disseminated cancer cell dormancy: an awakening field

Epithelial-mesenchymal transitions in development and disease

Cancer statistics, 2014

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