Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
about
NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivoRepression of smoothened by patched-dependent (pro-)vitamin D3 secretionThe structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signalingPharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.Distinct roles of PTCH2 splice variants in Hedgehog signallingA small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injuryArsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effectorSonic hedgehog has a dual effect on the growth of retinal ganglion axons depending on its concentrationInhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedAgonizing hedgehog.Roughing up Smoothened: chemical modulators of hedgehog signalingThe therapeutic potential of modulators of the Hedgehog-Gli signaling pathwayCytological profiling: providing more haystacks for chemists' needles.Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI InhibitorsHedgehog signaling pathway in ovarian cancerHedgehog signaling pathway and its targets for treatment in basal cell carcinomaConserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary SignalingSecretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammalsHedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active SiteStructure and function of the Smoothened extracellular domain in vertebrate Hedgehog signalingStructural basis for Smoothened receptor modulation and chemoresistance to anticancer drugsStructural basis of Smoothened regulation by its extracellular domainsItraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growthA novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse modelFunctional characterization of putative cilia genes by high-content analysisNovel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia CellsProgenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activityLoss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalusRer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels.The use of mouse models to understand and improve cognitive deficits in Down syndrome.Stem cell biology and drug discovery.Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer.Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.Small molecules in stem cell self-renewal and differentiation.Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries.Solving the puzzle of Parkinson's disease using induced pluripotent stem cells.Converse conformational control of smoothened activity by structurally related small molecules.Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy.Chemical genetic screening in the zebrafish embryo.Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model
P2860
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P2860
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Small-molecule modulators of H ...... hened agonists and antagonists
@ast
Small-molecule modulators of H ...... hened agonists and antagonists
@en
Small-molecule modulators of H ...... hened agonists and antagonists
@nl
type
label
Small-molecule modulators of H ...... hened agonists and antagonists
@ast
Small-molecule modulators of H ...... hened agonists and antagonists
@en
Small-molecule modulators of H ...... hened agonists and antagonists
@nl
prefLabel
Small-molecule modulators of H ...... hened agonists and antagonists
@ast
Small-molecule modulators of H ...... hened agonists and antagonists
@en
Small-molecule modulators of H ...... hened agonists and antagonists
@nl
P2093
P2860
P3181
P356
P1433
P1476
Small-molecule modulators of H ...... hened agonists and antagonists
@en
P2093
David Bumcrot
Frank Y Wang
Henryk Dudek
Hynek Wichterle
Janine Shulok
Jeffery A Porter
Maria Frank-Kamenetsky
Oivin Guicherit
Simon Jones
Steve Bottega
P2860
P2888
P3181
P356
10.1186/1475-4924-1-10
P407
P50
P577
2002-11-06T00:00:00Z
P5875
P6179
1043011281