Insights into the role of heme in the mechanism of action of antimalarials.
about
Phospholipid membrane-mediated hemozoin formation: the effects of physical properties and evidence of membrane surrounding hemozoinA genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in KenyaArtemisinin Action and Resistance in Plasmodium falciparumMefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitroMolecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance TransporterInhibition of an Erythrocyte Tyrosine Kinase with Imatinib Prevents Plasmodium falciparum Egress and Terminates ParasitemiaEvolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole PhysiologyHemozoin and antimalarial drug discoveryMalarial hemozoin: from target to toolIdentification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity.Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity.Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug PiperaquineInsights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.Identification of β-hematin inhibitors in the MMV Malaria BoxOptimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials.Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model.Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.Breakdown of phosphatidylserine asymmetry following treatment of erythrocytes with lumefantrine.Quantification of labile heme in live malaria parasites using a genetically encoded biosensorDual-functioning antimalarials that inhibit the chloroquine-resistance transporter.Adverse neuropsychiatric effects of antimalarial drugs.Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparumHexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.Detergent-Mediated Formation of β-Hematin: Heme Crystallization Promoted by Detergents Implicates Nanostructure Formation for Use as a Biological Mimic.Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs.ATP and luciferase assays to determine the rate of drug action in in vitro cultures of Plasmodium falciparum.The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition.Plasmodium heme biosynthesis: To be or not to be essential?Synthetic Hemozoin (β-Hematin) Crystals Nucleate at the Surface of Neutral Lipid Droplets that Control Their Sizes.A computational study of ligand binding affinities in iron(III) porphine and protoporphyrin IX complexes.Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum.Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum.High-Content Screening of MMV Pathogen Box for Plasmodium falciparum Digestive Vacuole Disrupting Molecules Reveals Valuable Starting Points for Drug Discovery.Genotoxic effects of the antimalarial drug lumefantrine in human lymphocytes in vitro and computational prediction of the mechanism associated with its interaction with DNA.Palladium-catalyzed intermolecular oxidative cyclization of N-aryl enamines with isocyanides through double sp(2) C-H bonds cleavage: facile synthesis of 4-aminoquinoline derivatives.Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains
P2860
Q21559583-B407CD9B-5E43-4A55-ABD9-B27AB43B08F5Q28031418-B8F264A1-FDCD-458D-80AD-957E3D7637DBQ28276294-22D09963-88DB-4AA5-94AC-7F330D74FBDDQ28307141-C6033DF9-85CA-42CD-AC0D-1BDA7555B8B5Q28552775-5B7C82D2-0064-42C4-AE47-87D392BE206FQ28552868-1CEEA001-344D-40B8-B411-45B8756EFF97Q28553454-74E24837-85AB-44C6-977D-1571ED13F107Q28828253-9411390A-D3D4-456D-9F5F-A0ECC1F9E5E6Q30410108-2F016CE8-86BA-4FD4-9C0D-E1F44E8DD08AQ30422848-A266A01B-6295-479C-AEB5-71AEA637EE42Q30883690-5FE04776-A39C-4885-8FA8-DBA0DFD5136FQ33635667-B82C9EC3-8517-49B8-B4BC-664D926047AAQ33654512-3193CB13-F21E-4035-AFFC-6A87BEE85B48Q33919526-C89F0AE1-A86D-406E-8AEE-54EDB95C8297Q35684978-F81613B3-0BEA-46C2-9E23-54650F249E1CQ35794627-7F656EE4-1370-4E6D-AF97-9A46F86697C9Q36376756-9EAE05DB-62A1-40E9-8519-23525A6AB804Q36904205-8981595A-6CB7-4ED5-BEA1-1F8C4E990FA9Q36919648-2C0BF8FA-A006-4726-B60C-0D95DC864D0BQ37095658-9F09344F-7D21-4EE9-9A6D-9C79A911CE8AQ37617809-68D6F74E-F6B2-4D83-936D-17E06E966AC1Q37711617-9630C110-B8E8-4F82-836E-7234CD1197D9Q38093645-BD2AED0A-26C2-4477-891D-09812146A50CQ38808162-34E6E87B-A554-4A1C-9C62-49F394528D24Q38868865-55B99D66-52E6-4F73-B0C4-A45C7D6D8ACCQ39552647-CA0DAA4A-56BD-4A07-B800-773A85B5D35FQ39769655-166C3CD3-2F07-421E-B758-2CE173240EE2Q40106428-ACD33E14-865E-47AE-8982-DE970F904CBAQ41119883-3625A6C6-4244-4DA6-8BAC-2DB1C5064588Q41811714-11D3726D-2091-4AC8-A460-E5B75D355A26Q41925428-33622CFF-8D86-46AE-AE84-0BED1DBB31C8Q42366297-A06273F9-782A-4D22-A27D-2AA7D47A8270Q42909136-06391164-A22A-4266-BD53-0C638127E2CCQ46284797-D6C49A98-F4B2-4C06-A0DC-4D7ECDE66A97Q46310228-86A1BA0C-FD10-4B45-87EA-E455A130283EQ46984380-B2BBECEF-CD2C-41CD-A115-E18A8CF1DCC0Q47193275-FA42F8ED-F3C2-4B2D-8E9C-693E86F9AB9CQ47907117-8FABFB8E-7B79-4013-8168-D2AD7B23DD45Q52957108-94E196B7-B0A7-43B1-81B6-91598D4BDDA0Q56342161-BE6E81C6-F0FC-4131-BB33-81C134476E1E
P2860
Insights into the role of heme in the mechanism of action of antimalarials.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Insights into the role of heme in the mechanism of action of antimalarials.
@ast
Insights into the role of heme in the mechanism of action of antimalarials.
@en
type
label
Insights into the role of heme in the mechanism of action of antimalarials.
@ast
Insights into the role of heme in the mechanism of action of antimalarials.
@en
prefLabel
Insights into the role of heme in the mechanism of action of antimalarials.
@ast
Insights into the role of heme in the mechanism of action of antimalarials.
@en
P2093
P2860
P356
P1433
P1476
Insights into the role of heme in the mechanism of action of antimalarials.
@en
P2093
Dale Taylor
Jill M Combrinck
Kanyile K Ncokazi
Melvin A Ambele
Peter J Smith
Tebogo E Mabotha
Timothy J Egan
P2860
P304
P356
10.1021/CB300454T
P577
2012-10-11T00:00:00Z