B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.
about
Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1uA protease-independent function for SPPL3 in NFAT activationγ-Secretase inhibitors and modulators.Molecular mechanism and cellular function of MHCII ubiquitinationDifferential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase InhibitorsAutomated peptide mapping and protein-topographical annotation of proteomics data.Dissecting mammalian immunity through mutation.Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3.A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases.BAFF promotes proliferation of human mesangial cells through interaction with BAFF-RSignal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cellsAn Analysis of MIF Structural Features that Control Functional Activation of CD74.Comparison of predicted and actual consequences of missense mutations.Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery PatientsRelationship between elevated soluble CD74 and severity of experimental and clinical ALI/ARDSOverexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells.Immune Cell Repertoire and Their Mediators in Patients with Acute Myocardial Infarction or Stable Angina Pectoris.The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivoStructural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids.Structural biology of presenilins and signal peptide peptidases.MHC class II antigen presentation by dendritic cells regulated through endosomal sorting.Dynamics of the membrane-cytoskeleton interface in MHC class II-restricted antigen presentation.Invariant Chain Complexes and Clusters as Platforms for MIF Signaling.The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.Trial watch: Dendritic cell-based interventions for cancer therapy.Embedded in the Membrane: How Lipids Confer Activity and Specificity to Intramembrane Proteases.Intramembrane Proteolysis of Astrotactins.The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments.Macrophage Migration Inhibitory Factor (MIF) Prevents Maternal Death, but Contributes to Poor Fetal Outcome During Congenital Toxoplasmosis.
P2860
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P2860
B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
B cell survival, surface BCR a ...... membrane endopeptidase SPPL2A.
@ast
B cell survival, surface BCR a ...... membrane endopeptidase SPPL2A.
@en
type
label
B cell survival, surface BCR a ...... membrane endopeptidase SPPL2A.
@ast
B cell survival, surface BCR a ...... membrane endopeptidase SPPL2A.
@en
prefLabel
B cell survival, surface BCR a ...... membrane endopeptidase SPPL2A.
@ast
B cell survival, surface BCR a ...... membrane endopeptidase SPPL2A.
@en
P2093
P2860
P50
P356
P1476
B cell survival, surface BCR a ...... membrane endopeptidase SPPL2A.
@en
P2093
Alanna Short
Andrew J Rimmer
Belinda Whittle
Bhavani Balakishnan
Carla M Roots
Charis E Teh
Christopher C Goodnow
Edward M Bertram
Geoff Sjollema
Hannes Bergmann
P2860
P356
10.1084/JEM.20121076
P407
P577
2012-12-24T00:00:00Z