Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide
about
Engineered Autonomous Human Variable DomainsEfficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability.Methods of probing the interactions between small molecules and disordered proteins.Structural and functional diversity among amyloid proteins: Agents of disease, building blocks of biology, and implications for molecular engineering.Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies.Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate.Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs.
P2860
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P2860
Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
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2015年论文
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2015年论文
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name
Design and Optimization of Ant ...... and Islet Amyloid Polypeptide
@ast
Design and Optimization of Ant ...... and Islet Amyloid Polypeptide
@en
type
label
Design and Optimization of Ant ...... and Islet Amyloid Polypeptide
@ast
Design and Optimization of Ant ...... and Islet Amyloid Polypeptide
@en
prefLabel
Design and Optimization of Ant ...... and Islet Amyloid Polypeptide
@ast
Design and Optimization of Ant ...... and Islet Amyloid Polypeptide
@en
P2093
P2860
P356
P1476
Design and Optimization of Ant ...... and Islet Amyloid Polypeptide
@en
P2093
Christine C Lee
Fanling Meng
Kathryn E Tiller
Mark C Julian
Rehana Akter
Sarah E DuConge
P2860
P304
P356
10.1074/JBC.M115.682336
P407
P577
2015-11-24T00:00:00Z