The human growth hormone gene is regulated by a multicomponent locus control region.
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Locus control regionsThe prolactin and growth hormone families: pregnancy-specific hormones/cytokines at the maternal-fetal interfaceFunctional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHDEvidence for evolutionary conservation of a physical linkage between the human BAF60b, a subunit of SWI/SNF complex, and thyroid hormone receptor interacting protein-1 genes on chromosome 17Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repressionThe GH1/IGF-1 axis polymorphisms and their impact on breast cancer developmentSpatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locusExtensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.Ectopic T cell receptor-α locus control region activity in B cells is suppressed by direct linkage to two flanking genes at once.Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues.Dividing the empire: boundary chromatin elements delimit the territory of enhancers.The human growth hormone locus control region mediates long-distance transcriptional activation independent of nuclear matrix attachment regionsA new element within the T-cell receptor alpha locus required for tissue-specific locus control region activitySpecification of unique Pit-1 activity in the hGH locus control region.Research resource: T-antigen transformation of pituitary cells captures three novel cell lines in the Pit-1 lineage.The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone.Lentiviral and Moloney retroviral expression of green fluorescent protein in somatotrophs in vivo.The human vitamin D-binding protein gene contains locus control determinants sufficient for autonomous activation in hepatic chromatinPatterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region.CCAAT-enhancer-binding protein β (C/EBPβ) and downstream human placental growth hormone genes are targets for dysregulation in pregnancies complicated by maternal obesityThe role of the hGH locus control region in somatotrope restriction of hGH-N gene expression.Stability of protein production from recombinant mammalian cells.Energy homeostasis targets chromosomal reconfiguration of the human GH1 locusA single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functionsAutonomous actions of the human growth hormone long-range enhancerDeletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenesDominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons.Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapyA Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone.An RNA-independent linkage of noncoding transcription to long-range enhancer function.DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer functionEpigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation.B29 gene silencing in pituitary cells is regulated by its 3' enhancerNegative regulation of human growth hormone gene expression by insulin is dependent on hypoxia-inducible factor binding in primary non-tumor pituitary cells.Expression of Placental Members of the Human Growth Hormone Gene Family Is Increased in Response to Sequential Inhibition of DNA Methylation and Histone DeacetylationRegulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: suppression of a variegated cellular pattern of expression requires a full complement of distant ciDistinct chromatin configurations regulate the initiation and the maintenance of hGH gene expressionMolecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease.The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression.Molecular physiology of pituitary development: signaling and transcriptional networks.
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P2860
The human growth hormone gene is regulated by a multicomponent locus control region.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
The human growth hormone gene is regulated by a multicomponent locus control region.
@ast
The human growth hormone gene is regulated by a multicomponent locus control region.
@en
type
label
The human growth hormone gene is regulated by a multicomponent locus control region.
@ast
The human growth hormone gene is regulated by a multicomponent locus control region.
@en
prefLabel
The human growth hormone gene is regulated by a multicomponent locus control region.
@ast
The human growth hormone gene is regulated by a multicomponent locus control region.
@en
P2093
P2860
P356
P1476
The human growth hormone gene is regulated by a multicomponent locus control region.
@en
P2093
S A Liebhaber
P2860
P304
P356
10.1128/MCB.15.12.7010
P407
P577
1995-12-01T00:00:00Z