Spermine block of the strong inward rectifier potassium channel Kir2.1: dual roles of surface charge screening and pore block.
about
Inward rectifiers and their regulation by endogenous polyaminesMulti-ion versus single-ion conduction mechanisms can yield current rectification in biological ion channels.Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1.Functional consequences of Kir2.1/Kir2.2 subunit heteromerization.A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation.Revisiting inward rectification: K ions permeate through Kir2.1 channels during high-affinity block by spermidine.Multi-ion distributions in the cytoplasmic domain of inward rectifier potassium channels.Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics.The role of the cytoplasmic pore in inward rectification of Kir2.1 channelsMechanism of the voltage sensitivity of IRK1 inward-rectifier K+ channel block by the polyamine spermine.Ser165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the poreMolecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis.Long polyamines act as cofactors in PIP2 activation of inward rectifier potassium (Kir2.1) channelsElectrostatics in the cytoplasmic pore produce intrinsic inward rectification in kir2.1 channels.Blocker protection by short spermine analogs: refined mapping of the spermine binding site in a Kir channelTwo modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line.Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.Two Kir2.1 channel populations with different sensitivities to Mg(2+) and polyamine block: a model for the cardiac strong inward rectifier K(+) channel.Evidence for sequential ion-binding loci along the inner pore of the IRK1 inward-rectifier K+ channel.The bundle crossing region is responsible for the inwardly rectifying internal spermine block of the Kir2.1 channel.Mechanism of inward rectification in Kir channels.Conformational changes in Kir2.1 channels during NH4+-induced inactivation.Voltage-dependent gating and block by internal spermine of the murine inwardly rectifying K+ channel, Kir2.1.Inward rectification by polyamines in mouse Kir2.1 channels: synergy between blocking components.The effects of spermine on the accessibility of residues in the M2 segment of Kir2.1 channels expressed in Xenopus oocytes.Integration of K+ and Cl- currents regulate steady-state and dynamic membrane potentials in cultured rat microglia.Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels.Flow- and voltage-dependent blocking effect of ethosuximide on the inward rectifier K⁺ (Kir2.1) channel.Phosphatidylinositol-4,5-bisphosphate (PIP2) regulation of strong inward rectifier Kir2.1 channels: multilevel positive cooperativity.Regulation of gating by negative charges in the cytoplasmic pore in the Kir2.1 channel.Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating.Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.Kir2 inward rectification-controlled precise and dynamic balances between Kir2 and HCN currents initiate pacemaking activity.
P2860
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P2860
Spermine block of the strong inward rectifier potassium channel Kir2.1: dual roles of surface charge screening and pore block.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Spermine block of the strong i ...... arge screening and pore block.
@ast
Spermine block of the strong i ...... arge screening and pore block.
@en
type
label
Spermine block of the strong i ...... arge screening and pore block.
@ast
Spermine block of the strong i ...... arge screening and pore block.
@en
prefLabel
Spermine block of the strong i ...... arge screening and pore block.
@ast
Spermine block of the strong i ...... arge screening and pore block.
@en
P2093
P2860
P356
P1476
Spermine block of the strong i ...... arge screening and pore block.
@en
P2093
James N Weiss
Lai-Hua Xie
Scott A John
P2860
P356
10.1085/JGP.20028576
P577
2002-07-01T00:00:00Z