Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
about
In silico screening of the key cellular remodeling targets in chronic atrial fibrillationPharmacological inhibition of IK1 by PA-6 in isolated rat hearts affects ventricular repolarization and refractorinessCardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models.PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression.Electrophysiologic effects of the IK1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts.Partial IK1 blockade destabilizes spiral wave rotation center without inducing wave breakup and facilitates termination of reentrant arrhythmias in ventricles.Cardiac Arrhythmias and Antiarrhythmic Drugs: An Autophagic Perspective.Efficacy of pentamidine analogue 6 in dogs with chronic atrial fibrillation
P2860
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P2860
Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
description
2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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name
Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
@en
Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
@nl
type
label
Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
@en
Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
@nl
prefLabel
Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
@en
Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
@nl
P2093
P2860
P356
P1476
Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
@en
P2093
Anna Stary-Weinzinger
Hiroki Takanari
Kathy C G de Git
Lukas Nalos
Maaike Peschar
Marc A Vos
Marcel A G van der Heyden
Marien J C Houtman
Martin B Rook
Richard R Tidwell
P2860
P304
P356
10.1093/CVR/CVT103
P577
2013-04-25T00:00:00Z